TY - JOUR
T1 - Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination
AU - Gómez Preciado, Francisco
AU - De Carvalho Ovalles, Rosa Alejandra
AU - Codina, Sergi
AU - Donadeu, Laura
AU - Favà, Alexandre
AU - Martinez Valenzuela, Laura
AU - Sandoval, Diego
AU - Fernández-Cidón, Bárbara
AU - Bestard, Oriol
AU - Alia-Ramos, Pedro
AU - Gomà-i-Freixanet, Montserrat
AU - Melilli, Edoardo
AU - Cruzado, Josep María
PY - 2022
Y1 - 2022
N2 - With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.
AB - With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.
KW - SARS-CoV-2
KW - Vaccine
KW - COVID-19
KW - Collapsing
KW - Glomerulonephritis
KW - mRNA
UR - https://www.scopus.com/pages/publications/85132760837
U2 - 10.3390/jcm11133651
DO - 10.3390/jcm11133651
M3 - Article
C2 - 35806939
SN - 2077-0383
VL - 11
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -
