TY - JOUR
T1 - Cobalt mediated regioselective alkylation of methyl 3,5-dioxohexanote. Preparation of 5-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone
AU - Cervelló, Jordi
AU - Marquet, Jorge
AU - Moreno-Mañas, Marcial
PY - 1987/12/1
Y1 - 1987/12/1
N2 - The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-6-methyl-2- pyrones.
AB - The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-6-methyl-2- pyrones.
U2 - 10.1039/C39870000644
DO - 10.1039/C39870000644
M3 - Article
SN - 0022-4936
SP - 644
EP - 645
JO - Journal of the Chemical Society D: Chemical Communications
JF - Journal of the Chemical Society D: Chemical Communications
IS - 9
ER -