Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells

Pedro Martinez; JoséM M. Vidal; Claudio Monsalves; Mercè Pérez; Carmie Pucket; Imma Ponte; Pedro Suau

doi:10.1016/0378-1119

Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells

Pedro Martinez, JoséM M. Vidal, Claudio Monsalves, Mercè Pérez, Carmie Pucket, Imma Ponte, Pedro Suau

Departament de Bioquímica i de Biologia Molecular

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

5 Cites (Scopus)

Resum

We have determined the complete coding sequence of the histone-encoding H1° gene from rat PC12 cells. Southern and Northern analyses suggest that rat H1° is encoded by a single-copy gene which generates an mRNA of about 2.2 kb. Comparison of the rat, mouse and human amino-acid sequences shows that the C-terminal domain of the protein is much more variable than the N-terminal and central domains. Rates of non-synonymous and synonymous nucleotide substitution have been calculated. The rate of non-synonymous substitution is about 2.5-times higher in the rodent lineage than in the human lineage. © 1995.

Idioma original	Anglès
Pàgines (de-a)	313-316
Nombre de pàgines	4
Revista	Gene
Volum	166
Número	2
DOIs	https://doi.org/10.1016/0378-1119
Estat de la publicació	Publicada - 12 de des. 1995

Accés al document

10.1016/0378-1119

Altres arxius i enllaços

Mostra el registre a Web of Science

Com citar-ho

@article{6858e7b91d584ccb8fcfc4866ef00d29,

title = "Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells",

abstract = "We have determined the complete coding sequence of the histone-encoding H1° gene from rat PC12 cells. Southern and Northern analyses suggest that rat H1° is encoded by a single-copy gene which generates an mRNA of about 2.2 kb. Comparison of the rat, mouse and human amino-acid sequences shows that the C-terminal domain of the protein is much more variable than the N-terminal and central domains. Rates of non-synonymous and synonymous nucleotide substitution have been calculated. The rate of non-synonymous substitution is about 2.5-times higher in the rodent lineage than in the human lineage. {\textcopyright} 1995.",

keywords = "Molecular evolution, Neuron, Non-synonymous substitution",

author = "Pedro Martinez and Vidal, {Jos{\'e}M M.} and Claudio Monsalves and Merc{\`e} P{\'e}rez and Carmie Pucket and Imma Ponte and Pedro Suau",

year = "1995",

month = dec,

day = "12",

doi = "10.1016/0378-1119",

language = "English",

volume = "166",

pages = "313--316",

number = "2",

}

TY - JOUR

T1 - Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells

AU - Martinez, Pedro

AU - Vidal, JoséM M.

AU - Monsalves, Claudio

AU - Pérez, Mercè

AU - Pucket, Carmie

AU - Ponte, Imma

AU - Suau, Pedro

PY - 1995/12/12

Y1 - 1995/12/12

N2 - We have determined the complete coding sequence of the histone-encoding H1° gene from rat PC12 cells. Southern and Northern analyses suggest that rat H1° is encoded by a single-copy gene which generates an mRNA of about 2.2 kb. Comparison of the rat, mouse and human amino-acid sequences shows that the C-terminal domain of the protein is much more variable than the N-terminal and central domains. Rates of non-synonymous and synonymous nucleotide substitution have been calculated. The rate of non-synonymous substitution is about 2.5-times higher in the rodent lineage than in the human lineage. © 1995.

AB - We have determined the complete coding sequence of the histone-encoding H1° gene from rat PC12 cells. Southern and Northern analyses suggest that rat H1° is encoded by a single-copy gene which generates an mRNA of about 2.2 kb. Comparison of the rat, mouse and human amino-acid sequences shows that the C-terminal domain of the protein is much more variable than the N-terminal and central domains. Rates of non-synonymous and synonymous nucleotide substitution have been calculated. The rate of non-synonymous substitution is about 2.5-times higher in the rodent lineage than in the human lineage. © 1995.

KW - Molecular evolution

KW - Neuron

KW - Non-synonymous substitution

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uab_pure&SrcAuth=WosAPI&KeyUT=WOS:A1995TL60000022&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/0378-1119

DO - 10.1016/0378-1119

M3 - Article

C2 - 8543182

SN - 0378-1119

VL - 166

SP - 313

EP - 316

JO - Gene

JF - Gene

IS - 2

ER -

Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells

Resum

Accés al document

Altres arxius i enllaços

Fingerprint

Com citar-ho