TY - JOUR
T1 - Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain
AU - Soriano-Arandes, Antoni
AU - Frick, Marie Antoinette
AU - García López-Hortelano, Milagros
AU - Sulleiro Igual, Elena
AU - Rodó, Carlota
AU - Sánchez-Seco, María Paz
AU - Cabrera-Lafuente, Marta
AU - Suy, Anna
AU - De la Calle, María
AU - Santos, Mar
AU - Antolin, Eugenia
AU - Viñuela, María del Carmen
AU - Espiau, María
AU - Salazar, Ainara
AU - Guarch-Ibáñez, Borja
AU - Vázquez, Ana
AU - Navarro-Morón, Juan
AU - Ramos-Amador, José-Tomás
AU - Martín-Nalda, Andrea
AU - Dueñas, Eva
AU - Blázquez-Gamero, Daniel
AU - Reques-Cosme, Resurrección
AU - Olabarrieta, Iciar
AU - Prieto, Luis
AU - De Ory, Fernando
AU - Thorne, Claire
AU - Byrne, Thomas
AU - Ades, Anthony E.
AU - Ruiz-Burga, Elisa
AU - Giaquinto, Carlo
AU - Garcia-Alix, Alfredo
AU - Carreras Moratonas, Elena
AU - Soler-Palacín, Pere
PY - 2020
Y1 - 2020
N2 - Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations
AB - Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations
KW - Zika virus
KW - Microcephaly
KW - Congenital infection
KW - Adverse outcome
KW - Arboviruses
UR - https://www.scopus.com/pages/publications/85084485626
U2 - 10.3390/pathogens9050352
DO - 10.3390/pathogens9050352
M3 - Article
C2 - 32392815
SN - 2076-0817
VL - 9
JO - Pathogens
JF - Pathogens
ER -
