TY - JOUR
T1 - Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study.
AU - Escrihuela-Vidal, F
AU - López-Cortés, LE
AU - Escolà-Vergé, L
AU - De, Alarcón González A
AU - Cuervo, G
AU - Sánchez-Porto, A
AU - Fernández-Hidalgo, N
AU - Luque, R
AU - Montejo, M
AU - Benito, Natividad
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2021/3/29
Y1 - 2021/3/29
N2 - Background: Although
Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption.
Methods: We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or
Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis.
Results: Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%,
P = .116); valve disorder, including perforation (22.2% vs 18.1%,
P = .584), pseudoaneurysm (16.7% vs 8.3%,
P = .108), or prosthesis dehiscence (1.4% vs 6.3%,
P = .170); paravalvular complications, including abscess (25% vs 18.8%,
P = .264) and intracardiac fistula (5.6% vs 3.5%,
P = .485); heart failure (34.7% vs 38.9%,
P = .655); or embolic events (41.7% vs 32.6%,
P = .248). Indications for surgery (70.8% vs 70.8%;
P = 1) and mortality (13.9% vs 16.7%;
P = .741) were similar between groups.
Conclusions: SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.
AB - Background: Although
Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption.
Methods: We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or
Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis.
Results: Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%,
P = .116); valve disorder, including perforation (22.2% vs 18.1%,
P = .584), pseudoaneurysm (16.7% vs 8.3%,
P = .108), or prosthesis dehiscence (1.4% vs 6.3%,
P = .170); paravalvular complications, including abscess (25% vs 18.8%,
P = .264) and intracardiac fistula (5.6% vs 3.5%,
P = .485); heart failure (34.7% vs 38.9%,
P = .655); or embolic events (41.7% vs 32.6%,
P = .248). Indications for surgery (70.8% vs 70.8%;
P = 1) and mortality (13.9% vs 16.7%;
P = .741) were similar between groups.
Conclusions: SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.
UR - http://europepmc.org/abstract/med/34189163
UR - https://www.mendeley.com/catalogue/a2db2b03-2906-38e7-8284-c0c7d9f8be5e/
UR - https://www.scopus.com/pages/publications/85127446427
U2 - 10.1093/ofid/ofab163
DO - 10.1093/ofid/ofab163
M3 - Article
C2 - 34189163
SN - 2328-8957
VL - 8
SP - ofab163
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 6
ER -