Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease

Berta María Pascual-Sedano, Jaime Kulisevsky, Frederic Sampedro, Saul Martinez-Horta, Andrea Horta, Michael J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesús, A.D Adarmes-Gómez, Fátima Carrillo, Arnau Puig-Davi, Florinda Roldan-Lora, Miquel Aguilar Barberà, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots-Foraster, Javier Ruiz-Martínez, Francisco Carrillo Padilla, Mercedes Pueyo-MorlansIsabel Gonzalez-Aramburu, Jon Infante-Ceberio, Jorge Hernandez-Vara, Oriol de Fàbregues-Boixar i Nebot, María Teresa de Deus Fonticoba, Asunción Ávila, Juan Carlos Martínez-Castrillo, Helena Bejr-Kasem Marco, Antonia Campolongo, Pablo Martínez-Martín, Diego Santos García, Pablo Mir, Pedro J García Ruiz

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Background and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
Idioma originalEnglish
RevistaEuropean Journal of Neurology
DOIs
Estat de la publicacióPublicada - 2022

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