Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

Marta Ferran; Ester R. Romeu; Catalina Rincón; Marc Sagristà; Ana M. Giménez Arnau; Antonio Celada; Ramon M. Pujol; Péter Holló; Hajnalka Jókai; Luis F. Santamaria-Babí

doi:10.1111/exd.12154

Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

Marta Ferran, Ester R. Romeu, Catalina Rincón, Marc Sagristà, Ana M. Giménez Arnau, Antonio Celada, Ramon M. Pujol, Péter Holló, Hajnalka Jókai, Luis F. Santamaria-Babí

Departament de Medicina

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Resum

T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases. © 2013 John Wiley & Sons A/S.

Idioma original	Anglès
Pàgines (de-a)	439-442
Revista	Experimental Dermatology
Volum	22
Número	7
DOIs	https://doi.org/10.1111/exd.12154
Estat de la publicació	Publicada - 1 de jul. 2013

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10.1111/exd.12154

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@article{5833c16a19ee470a960c03410c3344d0,

title = "Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases",

abstract = "T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases. {\textcopyright} 2013 John Wiley \& Sons A/S.",

keywords = "Associated antigen, Biomarker, Cutaneous lymphocyte, Skin-homing, T lymphocyte",

author = "Marta Ferran and Romeu, \{Ester R.\} and Catalina Rinc{\'o}n and Marc Sagrist{\`a} and \{Gim{\'e}nez Arnau\}, \{Ana M.\} and Antonio Celada and Pujol, \{Ramon M.\} and P{\'e}ter Holl{\'o} and Hajnalka J{\'o}kai and Santamaria-Bab{\'i}, \{Luis F.\}",

year = "2013",

month = jul,

day = "1",

doi = "10.1111/exd.12154",

language = "English",

volume = "22",

pages = "439--442",

journal = "Experimental Dermatology",

issn = "0906-6705",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

AU - Ferran, Marta

AU - Romeu, Ester R.

AU - Rincón, Catalina

AU - Sagristà, Marc

AU - Giménez Arnau, Ana M.

AU - Celada, Antonio

AU - Pujol, Ramon M.

AU - Holló, Péter

AU - Jókai, Hajnalka

AU - Santamaria-Babí, Luis F.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases. © 2013 John Wiley & Sons A/S.

AB - T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases. © 2013 John Wiley & Sons A/S.

KW - Associated antigen

KW - Biomarker

KW - Cutaneous lymphocyte

KW - Skin-homing

KW - T lymphocyte

UR - https://www.scopus.com/pages/publications/84879565956

U2 - 10.1111/exd.12154

DO - 10.1111/exd.12154

M3 - Article

SN - 0906-6705

VL - 22

SP - 439

EP - 442

JO - Experimental Dermatology

JF - Experimental Dermatology

IS - 7

ER -

Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

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