TY - JOUR
T1 - Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
AU - Rovira, Alex
AU - Marazuela, Paula
AU - Bonaterra-Pastra, Anna
AU - Faura, Júlia
AU - Penalba, Anna
AU - Pizarro Gonzálvez, Jesús
AU - Pancorbo, Olalla
AU - Rodríguez-Luna, David
AU - Vert, Carla
AU - Pujadas, Francesc
AU - Freijo, M. Mar
AU - Tur, Silvia
AU - Martínez-Zabaleta, Maite
AU - Vera, Rocío
AU - Lebrato-Hernández, Lucia
AU - Arenillas, Juan F..
AU - Pérez-Sánchez, Soledad
AU - Montaner, Joan
AU - Delgado Martínez, María Pilar
AU - Hernandez Guillamon, Maria Mar
PY - 2021
Y1 - 2021
N2 - Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH
AB - Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH
KW - Aquaporin 4
KW - Cerebral amyloid angiopathy
KW - Intracerebral hemorrhage
KW - Magnetic resonance imaging markers
KW - Functional outcome
U2 - 10.3390/jcm10050989
DO - 10.3390/jcm10050989
M3 - Article
C2 - 33801197
SN - 2077-0383
VL - 10
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -