Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis

E. Cantó, F. Reverter, C. Morcillo-Suárez, F. Matesanz, O. Fernández, G. Izquierdo, K. Vandenbroeck, A. Rodríguez-Antigüedad, E. Urcelay, R. Arroyo, D. Otaegui, J. Olascoaga, A. Saiz, A. Navarro, A. Sanchez, C. Domínguez, A. Caminero, A. Horga, M. Tintoré, X. MontalbanManuel Comabella*

*Autor corresponent d’aquest treball

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Resum

Background: Chitinase 3-like 1 (CHI3L1) is upregulated in a wide variety of inflammatory conditions. Recent studies have pointed to a role of CHI3L1 in multiple sclerosis (MS) pathogenesis. Objective: The objective of this study was to investigate the role of plasma CHI3L1 in MS clinical course and disease activity and to evaluate the effect of interferon-beta (IFNβ) treatment on protein levels. Methods: Plasma CHI3L1 levels were determined by ELISA in 57 healthy controls (HC), 220 untreated MS patients [66 primary progressive MS patients (PPMS), 30 secondary progressive MS patients (SPMS), and 124 relapsing-remitting MS patients (RRMS), 94 during clinical remission and 30 during relapse], and 32 MS patients receiving IFNβ treatment. A polymorphism of the CHI3L1 gene, rs4950928, was genotyped in 3274 MS patients and 3483 HC. Results: Plasma CHI3L1 levels were significantly increased in patients with progressive forms of MS compared with RRMS patients and HC. CHI3L1 levels were similar between RRMS patients in relapse and remission. A trend towards decreased CHI3L1 levels was observed in IFNβ-treated patients. Allele C of rs4950928 was significantly associated with PPMS patients and with higher plasma CHI3L1 levels. Conclusions: These findings point to a role of CHI3L1 in patients with progressive forms of MS, particularly in those with PPMS.
Idioma originalAnglès
Pàgines (de-a)983-990
Nombre de pàgines8
RevistaMultiple Sclerosis Journal
Volum18
Número7
DOIs
Estat de la publicacióPublicada - de jul. 2012

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