Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

Clara Matute-Blanch; Jordi Río; Luisa M. Villar; Luciana Midaglia; Sunny Malhotra; José C. Álvarez-Cermeño; Angela Vidal-Jordana; Xavier Montalban; Manuel Comabella

doi:10.1016/j.jneuroim.2016.12.006

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

Clara Matute-Blanch, Jordi Río, Luisa M. Villar, Luciana Midaglia, Sunny Malhotra, José C. Álvarez-Cermeño, Angela Vidal-Jordana, Xavier Montalban, Manuel Comabella

Departament de Medicina

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© 2016 Elsevier B.V. Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFNβ-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFNβ (p = 0.830). CHI3L1 was associated with IFNβ response and levels were higher in non-responder group (p = 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFNβ in RRMS patients.

Idioma original	Anglès
Pàgines (de-a)	62-65
Revista	Journal of Neuroimmunology
Volum	303
DOIs	https://doi.org/10.1016/j.jneuroim.2016.12.006
Estat de la publicació	Publicada - 15 de febr. 2017

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10.1016/j.jneuroim.2016.12.006

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@article{f21f83a028f64f689d9fd4adf6055fd9,

title = "Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis",

abstract = "{\textcopyright} 2016 Elsevier B.V. Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFNβ-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFNβ (p = 0.830). CHI3L1 was associated with IFNβ response and levels were higher in non-responder group (p = 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFNβ in RRMS patients.",

keywords = "Biomarkers, Chitinase 3-like 1, Glatiramer acetate, Interferon-beta, Multiple sclerosis",

author = "Clara Matute-Blanch and Jordi R{\'i}o and Villar, {Luisa M.} and Luciana Midaglia and Sunny Malhotra and {\'A}lvarez-Cerme{\~n}o, {Jos{\'e} C.} and Angela Vidal-Jordana and Xavier Montalban and Manuel Comabella",

year = "2017",

month = feb,

day = "15",

doi = "10.1016/j.jneuroim.2016.12.006",

language = "English",

volume = "303",

pages = "62--65",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

AU - Matute-Blanch, Clara

AU - Río, Jordi

AU - Villar, Luisa M.

AU - Midaglia, Luciana

AU - Malhotra, Sunny

AU - Álvarez-Cermeño, José C.

AU - Vidal-Jordana, Angela

AU - Montalban, Xavier

AU - Comabella, Manuel

PY - 2017/2/15

Y1 - 2017/2/15

N2 - © 2016 Elsevier B.V. Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFNβ-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFNβ (p = 0.830). CHI3L1 was associated with IFNβ response and levels were higher in non-responder group (p = 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFNβ in RRMS patients.

AB - © 2016 Elsevier B.V. Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFNβ-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFNβ (p = 0.830). CHI3L1 was associated with IFNβ response and levels were higher in non-responder group (p = 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFNβ in RRMS patients.

KW - Biomarkers

KW - Chitinase 3-like 1

KW - Glatiramer acetate

KW - Interferon-beta

KW - Multiple sclerosis

U2 - 10.1016/j.jneuroim.2016.12.006

DO - 10.1016/j.jneuroim.2016.12.006

M3 - Article

SN - 0165-5728

VL - 303

SP - 62

EP - 65

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

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