Chiral Recognition by Dissolution DNP NMR Spectroscopy of 13C-Labeled dl -Methionine

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

18 Cites (Scopus)

Resum

© 2017 American Chemical Society. A method based on d-DNP NMR spectroscopy to study chiral recognition is described for the first time. The enantiodifferentiation of a racemic metabolite in a millimolar aqueous solution using a chiral solvating agent was performed. Hyperpolarized 13C-labeled dl-methionine enantiomers were differently observed with a single-scan 13C NMR experiment, while the chiral auxiliary at thermal equilibrium remained unobserved. The method developed entails a step forward in the chiral recognition of small molecules by NMR spectroscopy, opening new possibilities in situations where the sensitivity is limited, for example, when a low concentration of analyte is available or when the measurement of an insensitive nucleus, like 13C, is required. The advantages and current limitations of the method, as well as future perspectives, are discussed.
Idioma originalAnglès
Pàgines (de-a)4939-4944
RevistaAnalytical Chemistry
Volum89
Número9
DOIs
Estat de la publicacióPublicada - 2 de maig 2017

Fingerprint

Navegar pels temes de recerca de 'Chiral Recognition by Dissolution DNP NMR Spectroscopy of 13C-Labeled dl -Methionine'. Junts formen un fingerprint únic.

Com citar-ho