Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look

M. B. Ojeda-González; I. Alvárez-López; M. C. Alonso-Muñoz; J. Badía-Serra; E. Delgado-Latre; L. De Andrés- Basauri; J. J. López- L Ó Pez

doi:10.1159/000226885

Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look

M. B. Ojeda-González, I. Alvárez-López, M. C. Alonso-Muñoz, J. Badía-Serra, E. Delgado-Latre, L. De Andrés- Basauri, J. J. López- L Ó Pez

Departament de Pediatria, d’Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Setanta-dos pacients amb càncer d'ovari avançat van rebre quimioteràpia CAP seguida de laparotomia i cirurgia de 'segon intent'. La resposta global a la teràpia CAP va ser del 8ль% en 16 pacients, i respostes microscòpiques parcials (PMiR) i macroscòpiques es van obtenir en 7 i 33 casos respectivament. L'estadística de supervivència per al grup sencer va ser del 36% als 50 mesos amb una mitjana de supervivència de 34 mesos. No hi ha hagut cap diferència significativa entre la taxa de supervivència dels grups CPR i PMiR. La cirurgia radical de segon intent va mostrar un efecte lleugerament beneficiós. La mida del tumor abans de la quimioteràpia (<5 cm) i l'estadi FIGO III van tenir un efecte significativament favorable en la taxa de resposta i la supervivència. © 1991 S. Karger AG, Basel.

Idioma original	Anglès
Pàgines (de-a)	7-12
Revista	Oncology (Switzerland)
Volum	48
Número	1
DOIs	https://doi.org/10.1159/000226885
Estat de la publicació	Publicada - 1 de gen. 1991

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10.1159/000226885

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@article{1d0d8d4e18a34eb88a91d0948d3a5c04,

title = "Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look",

abstract = "Seventy-two patients with advanced ovarian cancer received CAP chemotherapy followed by laparotomy and {\textquoteleft}second-effort{\textquoteright} surgery. The overall response to CAP therapy was 80\%. A complete pathological response (CPR) was obtained in 16 patients and partial microscopic (PMiR) and macroscopic responses in 7 and 33 cases, respectively. The actuarial survival for the entire group was 36\% at 50 months with a median survival of 34 months. No significant differences in survival between the CPR and PMiR groups were found. Radical second-effort surgery showed a somewhat beneficial effect. The tumor size before chemotherapy (<5 cm) and FIGO stage III had a significantly favorable effect on response rate and survival. {\textcopyright} 1991 S. Karger AG, Basel.",

keywords = "Adriamycin, Advanced ovarian cancer, Chemotherapy, Cisplatin, Cyclophosphamide, Doxorubicin, Laparotomy, Ovarian cancer, FIGO stages III and IV, Second-effort surgery, Second-look",

author = "Ojeda-Gonz{\'a}lez, \{M. B.\} and I. Alv{\'a}rez-L{\'o}pez and Alonso-Mu{\~n}oz, \{M. C.\} and J. Bad{\'i}a-Serra and E. Delgado-Latre and \{De Andr{\'e}s- Basauri\}, L. and \{L{\'o}pez- L {\'O} Pez\}, \{J. J.\}",

year = "1991",

month = jan,

day = "1",

doi = "10.1159/000226885",

language = "English",

volume = "48",

pages = "7--12",

journal = "Oncology (Switzerland)",

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TY - JOUR

T1 - Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look

AU - Ojeda-González, M. B.

AU - Alvárez-López, I.

AU - Alonso-Muñoz, M. C.

AU - Badía-Serra, J.

AU - Delgado-Latre, E.

AU - De Andrés- Basauri, L.

AU - López- L Ó Pez, J. J.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Seventy-two patients with advanced ovarian cancer received CAP chemotherapy followed by laparotomy and ‘second-effort’ surgery. The overall response to CAP therapy was 80%. A complete pathological response (CPR) was obtained in 16 patients and partial microscopic (PMiR) and macroscopic responses in 7 and 33 cases, respectively. The actuarial survival for the entire group was 36% at 50 months with a median survival of 34 months. No significant differences in survival between the CPR and PMiR groups were found. Radical second-effort surgery showed a somewhat beneficial effect. The tumor size before chemotherapy (<5 cm) and FIGO stage III had a significantly favorable effect on response rate and survival. © 1991 S. Karger AG, Basel.

AB - Seventy-two patients with advanced ovarian cancer received CAP chemotherapy followed by laparotomy and ‘second-effort’ surgery. The overall response to CAP therapy was 80%. A complete pathological response (CPR) was obtained in 16 patients and partial microscopic (PMiR) and macroscopic responses in 7 and 33 cases, respectively. The actuarial survival for the entire group was 36% at 50 months with a median survival of 34 months. No significant differences in survival between the CPR and PMiR groups were found. Radical second-effort surgery showed a somewhat beneficial effect. The tumor size before chemotherapy (<5 cm) and FIGO stage III had a significantly favorable effect on response rate and survival. © 1991 S. Karger AG, Basel.

KW - Adriamycin

KW - Advanced ovarian cancer

KW - Chemotherapy

KW - Cisplatin

KW - Cyclophosphamide

KW - Doxorubicin

KW - Laparotomy

KW - Ovarian cancer, FIGO stages III and IV

KW - Second-effort surgery

KW - Second-look

UR - https://www.scopus.com/pages/publications/0026067948

U2 - 10.1159/000226885

DO - 10.1159/000226885

M3 - Article

SN - 0030-2414

VL - 48

SP - 7

EP - 12

JO - Oncology (Switzerland)

JF - Oncology (Switzerland)

IS - 1

ER -

Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look

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