TY - JOUR
T1 - Cerebrospinal Fluid Anti-Amyloid-Beta; Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation
AU - Carmona-Iragui, Maria
AU - Fernández-Arcos, Ana
AU - Alcolea, Daniel
AU - Piazza, Fabrizio
AU - Morenas-Rodriguez, Estrella
AU - Antón-Aguirre, Sofia
AU - Sala, Isabel
AU - Clarimon, Jordi
AU - Dols-Icardo, Oriol
AU - Camacho, Valle
AU - Sampedro, Frederic
AU - Munuera, Josep
AU - Nuñez-Marin, Fidel
AU - Lleó, Alberto
AU - Fortea, Juan
AU - Gómez-Ansón, Beatriz
AU - Blesa, Rafael
PY - 2016/1/1
Y1 - 2016/1/1
N2 - © 2016 - IOS Press and the authors. All rights reserved. We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreasedAβ40 andAβ42. After treatment, focal symptomatology disappeared, andWMLand anti-Aβautoantibodies decreased. TheAPOEε4 allelewas overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
AB - © 2016 - IOS Press and the authors. All rights reserved. We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreasedAβ40 andAβ42. After treatment, focal symptomatology disappeared, andWMLand anti-Aβautoantibodies decreased. TheAPOEε4 allelewas overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
KW - Biomarkers
KW - cerebral amyloid angiopathy
KW - cerebrospinal fluid
KW - Florbetapir-PET
KW - inflammation
U2 - 10.3233/JAD-150614
DO - 10.3233/JAD-150614
M3 - Article
SN - 1387-2877
VL - 50
SP - 1
EP - 7
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -