Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16^INK4a deficiency and telomere-dependent genotoxic stress

Keyphrases

• Aberrations 20%
• Breast Carcinogenesis 20%
• Cancer Development 20%
• Cell Culture 20%
• Centriole 20%
• Centrosome 20%
• Centrosome Aberrations 100%
• Centrosome Abnormalities 20%
• Centrosome Defects 20%
• Checkpoint Activation 20%
• Checkpoint Response 20%
• Chromosomal Instability 60%
• Cooperative Interaction 100%
• Diploid Cell 20%
• Distinct Mechanism 20%
• DNA Damage Checkpoint 40%
• Genotoxic Stress 100%
• Human Cancer 20%
• Human Mammary Epithelial Cells 100%
• Human Telomerase Reverse Transcriptase (hTERT) 40%
• In Cancer 40%
• Neoplastic Disease 20%
• P16INK4a 100%
• Polyploid 40%
• Polyploid Cells 20%
• Progressive Reduction 20%
• Radiation-induced DNA Damage 20%
• Telomere 100%
• Telomere Dysfunction 60%
• Tumor Protein p53 (TP53) 20%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 12%
• Cell Culture 12%
• Centriole 12%
• Centrosome 100%
• Chromosome Instability 37%
• Diploidy 12%
• DNA Damage 12%
• DNA Damage Checkpoint 25%
• P53 12%
• Polyploid 37%
• Telomere 100%