Cellular immune responses in multiple sclerosis patients treated with interferon-beta

M. F. Bustamante; J. Rio; Z. Castro; A. Sánchez; X. Montalban; M. Comabella

doi:10.1111/cei.12016

Cellular immune responses in multiple sclerosis patients treated with interferon-beta

M. F. Bustamante, J. Rio, Z. Castro, A. Sánchez, X. Montalban, M. Comabella

Departament de Medicina

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We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

Idioma original	Anglès
Pàgines (de-a)	243-246
Revista	Clinical and Experimental Immunology
Volum	171
Número	3
DOIs	https://doi.org/10.1111/cei.12016
Estat de la publicació	Publicada - 1 de març 2013

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10.1111/cei.12016

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title = "Cellular immune responses in multiple sclerosis patients treated with interferon-beta",

abstract = "We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. {\textcopyright} 2012 British Society for Immunology.",

keywords = "Cellular immunity, Cytokines, Interferon-beta, Multiple sclerosis, Treatment response",

author = "Bustamante, {M. F.} and J. Rio and Z. Castro and A. S{\'a}nchez and X. Montalban and M. Comabella",

year = "2013",

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doi = "10.1111/cei.12016",

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T1 - Cellular immune responses in multiple sclerosis patients treated with interferon-beta

AU - Bustamante, M. F.

AU - Rio, J.

AU - Castro, Z.

AU - Sánchez, A.

AU - Montalban, X.

AU - Comabella, M.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

AB - We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders. © 2012 British Society for Immunology.

KW - Cellular immunity

KW - Cytokines

KW - Interferon-beta

KW - Multiple sclerosis

KW - Treatment response

U2 - 10.1111/cei.12016

DO - 10.1111/cei.12016

M3 - Article

SN - 0009-9104

VL - 171

SP - 243

EP - 246

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 3

ER -

Cellular immune responses in multiple sclerosis patients treated with interferon-beta

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