CBT4CBT web-based add-on treatment for cocaine use disorder :: Study protocol for a randomized controlled trial

Núria Mallorquí-Bagué; A. Palazón-Llecha; Mercè Madre Rull; Francesca Batlle; Santiago Duran-Sindreu; Joan Trujols

doi:10.3389/fpsyt.2023.1051528

CBT4CBT web-based add-on treatment for cocaine use disorder : Study protocol for a randomized controlled trial

Núria Mallorquí-Bagué, A. Palazón-Llecha, Mercè Madre Rull, Francesca Batlle, Santiago Duran-Sindreu, Joan Trujols

Departament de Psiquiatria i Medicina Legal

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

3 Cites (Scopus)

Resum

El trastorn per consum de cocaïna és una malaltia crònica que presenta taxes elevades de recaiguda i abandonament del tractament. Les intervencions basades en la web han demostrat ser efectives quan s'optimitzen els tractaments presencials en diferents condicions de salut mental i tenen el potencial d'optimitzar els tractaments actuals contra el trastorn per consum de cocaïna. Tot i això, les intervencions basades en la web en conductes addictives encara són limitades. L'objectiu d'aquest estudi és avaluar si l'addició d'una teràpia cognitiva conductual basada en la web (és a dir, CBT4CBT) al tractament estàndard contra el trastorn per consum de cocaïna millora els resultats del tractament en una mostra espanyola de pacients amb un trastorn greu per consum de cocaïna (que requereix tractament hospitalari). A més, pretenem explorar els factors predictius de resposta al tractament i les diferències relacionades amb el sexe. Tots els individus que vinguin a desintoxicació de la cocaïna com a pacients interns que compleixin els criteris d'inclusió tindran l'oportunitat de participar en l'estudi. Els participants d'aquest assaig clínic obert aleatoritzat controlat (RCT) s'assignaran al tractament habitual (TAU) o TAU+CBT4CBT després de l'hospitalització per desintoxicació de la cocaïna. Durant el tractament hospitalari, tots rebran una intervenció psicològica individualitzada. Hi haurà sis avaluacions en diferents moments: a les 48-72 hores d'inici del tractament hospitalari, al final del tractament hospitalari i abans de començar l'atenció diürna i el tractament ambulatori, al final del tractament CTB4CBT/TAU de 8 setmanes i tres visites posteriors (1-, 3- i 6 mesos després del tractament). Fins on sabem, aquest és el primer RCT que explora l'eficàcia d'afegir una teràpia cognitiva conductual basada en la web al tractament estàndard contra el trastorn per consum de cocaïna amb pacients d'una mostra clínica a Europa. Registre de l'assaig: IIBSP-CTB-2020-116, NCT05207228. Presentat el 8 d'abril del 2021, publicat el 26 de gener del 2022.

Idioma original	Anglès
Revista	Frontiers in Psychiatry
Volum	14
DOIs	https://doi.org/10.3389/fpsyt.2023.1051528
Estat de la publicació	Publicada - 2023

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

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Accés al document

10.3389/fpsyt.2023.1051528

https://ddd.uab.cat/record/302801

Altres arxius i enllaços

https://www.scopus.com/pages/publications/85150390483

Com citar-ho

@article{37cfd21e225c442d9e7536e32cfcb565,

title = "CBT4CBT web-based add-on treatment for cocaine use disorder :: Study protocol for a randomized controlled trial",

abstract = "Cocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i.e., CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences. All individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48-72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment). To the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe. Trial registration: IIBSP-CTB-2020-116, NCT05207228. Submitted 8 of April 2021, posted 26 of January 2022. https://clinicaltrials.gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder\&draw=2\&rank=1.",

keywords = "Clinical trial, Cocaine use disorder, Cognitive behavioral therapy, Gender, Predictive factors, Protocol, Treatment, Treatment outcome",

author = "N{\'u}ria Mallorqu{\'i}-Bagu{\'e} and A. Palaz{\'o}n-Llecha and \{Madre Rull\}, Merc{\`e} and Francesca Batlle and Santiago Duran-Sindreu and Joan Trujols",

year = "2023",

doi = "10.3389/fpsyt.2023.1051528",

language = "English",

volume = "14",

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TY - JOUR

T1 - CBT4CBT web-based add-on treatment for cocaine use disorder :

T2 - Study protocol for a randomized controlled trial

AU - Mallorquí-Bagué, Núria

AU - Palazón-Llecha, A.

AU - Madre Rull, Mercè

AU - Batlle, Francesca

AU - Duran-Sindreu, Santiago

AU - Trujols, Joan

PY - 2023

Y1 - 2023

N2 - Cocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i.e., CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences. All individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48-72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment). To the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe. Trial registration: IIBSP-CTB-2020-116, NCT05207228. Submitted 8 of April 2021, posted 26 of January 2022. https://clinicaltrials.gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder&draw=2&rank=1.

AB - Cocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i.e., CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences. All individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48-72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment). To the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe. Trial registration: IIBSP-CTB-2020-116, NCT05207228. Submitted 8 of April 2021, posted 26 of January 2022. https://clinicaltrials.gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder&draw=2&rank=1.

KW - Clinical trial

KW - Cocaine use disorder

KW - Cognitive behavioral therapy

KW - Gender

KW - Predictive factors

KW - Protocol

KW - Treatment

KW - Treatment outcome

UR - https://www.scopus.com/pages/publications/85150390483

U2 - 10.3389/fpsyt.2023.1051528

DO - 10.3389/fpsyt.2023.1051528

M3 - Article

C2 - 36937712

SN - 1664-0640

VL - 14

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry