Caudoventral abdominal lymphangiosarcoma in a cat treated with metronomic chemotherapy

A 10-year-old, male neutered domestic shorthair cat was referred for reddish discolouration of its abdominal skin with serosanguineous discharge. The affected skin was bruised, nodular and had fluid-filled cavities. It was painful on palpation. A final diagnosis of lymphangiosarcoma was made by prospero-related homeobox gene-1 (PROX-1) immunohistochemistry. Metronomic chemotherapy treatment was instaured with toceranib phosphate, chlorambucil and meloxicam. Partial remission was achieved at 18 days and stable disease was maintained for 36 days (survival time: 54 days). Afterward, the tumour began to regrow aggressively and the patient developed anorexia; owners elected for euthanasia. Total survival time achieved was 63 days. To the authors' knowledge, this is the first case report of feline caudoventral abdominal lymphangiosarcoma treated with metronomic chemotherapy.