TY - JOUR
T1 - Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
AU - Tamborero, David
AU - Rubio-Perez, Carlota
AU - Deu-Pons, Jordi
AU - Schroeder, Michael P.
AU - Vivancos, Ana
AU - Rovira, Ana
AU - Tusquets, Ignasi
AU - Albanell, Joan
AU - Rodon, Jordi
AU - Tabernero, Josep
AU - de Torres, Carmen
AU - Dienstmann, Rodrigo
AU - Gonzalez-Perez, Abel
AU - Lopez-Bigas, Nuria
PY - 2018/3/28
Y1 - 2018/3/28
N2 - © 2018 The Author(s). While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.
AB - © 2018 The Author(s). While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.
U2 - 10.1186/s13073-018-0531-8
DO - 10.1186/s13073-018-0531-8
M3 - Article
SN - 1756-994X
VL - 10
JO - Genome Medicine
JF - Genome Medicine
IS - 1
M1 - 25
ER -
