Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

Robert Güerri-Fernández; Daniel Molina; Judit Villar-García; Daniel Prieto-Alhambra; Leonardo Mellibovsky; Xavier Nogués; Alicia González-Mena; Ana Guelar; Marta Trenchs-Rodríguez; Sabina Herrera-Fernández; Juan Pablo Horcajada; Adolfo Díez-Pérez; Hernando Knobel

doi:10.1097/QAI.0000000000000965

Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

Robert Güerri-Fernández^*, Daniel Molina, Judit Villar-García, Daniel Prieto-Alhambra, Leonardo Mellibovsky, Xavier Nogués, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Sabina Herrera-Fernández, Juan Pablo Horcajada, Adolfo Díez-Pérez, Hernando Knobel

^*Autor corresponent d’aquest treball

Departament de Medicina

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

34 Cites (Scopus)

Resum

Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

Idioma original	Anglès
Pàgines (de-a)	314-318
Nombre de pàgines	5
Revista	Journal of acquired immune deficiency syndromes (1999)
Volum	72
Número	3
DOIs	https://doi.org/10.1097/QAI.0000000000000965
Estat de la publicació	Publicada - 1 de jul. 2016

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

Accés al document

10.1097/QAI.0000000000000965

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https://www.scopus.com/pages/publications/84959131533

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Güerri-Fernández, R., Molina, D., Villar-García, J., Prieto-Alhambra, D., Mellibovsky, L., Nogués, X., González-Mena, A., Guelar, A., Trenchs-Rodríguez, M., Herrera-Fernández, S., Horcajada, J. P., Díez-Pérez, A., & Knobel, H. (2016). Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999), 72(3), 314-318. https://doi.org/10.1097/QAI.0000000000000965

Güerri-Fernández, Robert ; Molina, Daniel ; Villar-García, Judit et al. / Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density : HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. In: Journal of acquired immune deficiency syndromes (1999). 2016 ; Vol. 72, Núm. 3. pàg. 314-318.

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title = "Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density",

abstract = "Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.",

keywords = "BMD, bone material properties, HIV, microindentation",

author = "Robert G{\"u}erri-Fern{\'a}ndez and Daniel Molina and Judit Villar-Garc{\'i}a and Daniel Prieto-Alhambra and Leonardo Mellibovsky and Xavier Nogu{\'e}s and Alicia Gonz{\'a}lez-Mena and Ana Guelar and Marta Trenchs-Rodr{\'i}guez and Sabina Herrera-Fern{\'a}ndez and Horcajada, \{Juan Pablo\} and Adolfo D{\'i}ez-P{\'e}rez and Hernando Knobel",

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Güerri-Fernández, R, Molina, D, Villar-García, J, Prieto-Alhambra, D, Mellibovsky, L, Nogués, X, González-Mena, A, Guelar, A, Trenchs-Rodríguez, M, Herrera-Fernández, S, Horcajada, JP, Díez-Pérez, A & Knobel, H 2016, 'Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density', Journal of acquired immune deficiency syndromes (1999), vol. 72, núm. 3, pàg. 314-318. https://doi.org/10.1097/QAI.0000000000000965

Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. / Güerri-Fernández, Robert; Molina, Daniel; Villar-García, Judit et al.
In: Journal of acquired immune deficiency syndromes (1999), Vol. 72, Núm. 3, 01.07.2016, pàg. 314-318.

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

T2 - HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

AU - Güerri-Fernández, Robert

AU - Molina, Daniel

AU - Villar-García, Judit

AU - Prieto-Alhambra, Daniel

AU - Mellibovsky, Leonardo

AU - Nogués, Xavier

AU - González-Mena, Alicia

AU - Guelar, Ana

AU - Trenchs-Rodríguez, Marta

AU - Herrera-Fernández, Sabina

AU - Horcajada, Juan Pablo

AU - Díez-Pérez, Adolfo

AU - Knobel, Hernando

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

AB - Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

KW - BMD

KW - bone material properties

KW - HIV

KW - microindentation

UR - https://www.scopus.com/pages/publications/84959131533

U2 - 10.1097/QAI.0000000000000965

DO - 10.1097/QAI.0000000000000965

M3 - Article

C2 - 26910501

SN - 1525-4135

VL - 72

SP - 314

EP - 318

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

IS - 3

ER -

Güerri-Fernández R, Molina D, Villar-García J, Prieto-Alhambra D, Mellibovsky L, Nogués X et al. Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999). 2016 jul. 1;72(3):314-318. doi: 10.1097/QAI.0000000000000965