TY - JOUR
T1 - Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder
AU - Amann, Benedikt L.
AU - Canales-Rodriguez, Erick Jorge
AU - Madre Rull, Mercè
AU - Radua, Joaquim
AU - Monte, G.
AU - Alonso-Lana, Silvia
AU - Landin-Romero, Ramon
AU - Moreno Alcázar, Ana
AU - Bonnin, Caterina del Mar
AU - Sarró, S.
AU - Ortiz-Gil, J.
AU - Gomar, J. J.
AU - Moro, N.
AU - Fernandez-Corcuera, P.
AU - Goikolea, J. M.
AU - Blanch, J.
AU - Salvador, R.
AU - Vieta, Eduard
AU - McKenna, P. J.
AU - Pomarol-Clotet, E.
PY - 2015
Y1 - 2015
N2 - Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent. Forty-five patients meeting - and criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (). Analyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. The findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.
AB - Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent. Forty-five patients meeting - and criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (). Analyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. The findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.
KW - Neuroimaging
KW - Schizoaffective disorder
KW - Schizo-phrenia
KW - Bipolar disorder
KW - Voxel-based morphometry
U2 - 10.1111/acps.12440
DO - 10.1111/acps.12440
M3 - Article
C2 - 25968549
SN - 0001-690X
VL - 133
SP - 23
EP - 33
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - 1
ER -