TY - JOUR
T1 - Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials
AU - Rueda, Fabián
AU - Céspedes, María Virtudes
AU - Conchillo-Solé, Oscar
AU - Sánchez-Chardi, Alejandro
AU - Seras-Franzoso, Joaquin
AU - Cubarsi, Rafael
AU - Gallardo, Alberto
AU - Pesarrodona, Mireia
AU - Ferrer-Miralles, Neus
AU - Daura, Xavier
AU - Vázquez, Esther
AU - García-Fruitõs, Elena
AU - Mangues, Ramõn
AU - Unzueta, Ugutz
AU - Villaverde, Antonio
PY - 2015/12/16
Y1 - 2015/12/16
N2 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
AB - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
KW - biodistribution
KW - biofabrication
KW - cell quality control
KW - nanoparticles
KW - protein materials
U2 - 10.1002/adma.201503676
DO - 10.1002/adma.201503676
M3 - Article
SN - 0935-9648
VL - 27
SP - 7816
EP - 7822
JO - Advanced Materials
JF - Advanced Materials
ER -