Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Fabián Rueda, María Virtudes Céspedes, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Joaquin Seras-Franzoso, Rafael Cubarsi, Alberto Gallardo, Mireia Pesarrodona, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Elena García-Fruitõs, Ramõn Mangues, Ugutz Unzueta, Antonio Villaverde

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Resum

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
Idioma originalEnglish
Pàgines (de-a)7816-7822
RevistaAdvanced Materials
Volum27
DOIs
Estat de la publicacióPublicada - 16 de des. 2015

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