Biomarcadores en esclerosis múltiple

Guillermo Izquierdo, Óscar Fernández*, Mar Tintoré, Sergio Martínez-Yélamos, Rafael Arroyo-González, Manuel Comabella, Xavier Montalban, Juan A. García-Merino, José C. Álvarez-Cermeño, Celia Oreja-Guevara, Alfredo Rodríguez-Antigüedad, Lluís Ramió-Torrentà, José M. Prieto, Luisa M. Villar, José E. Meca-Lallana

*Autor corresponent d’aquest treball

Producció científica: Contribució a revistaArticle de revisióRecercaAvaluat per experts

6 Cites (Scopus)

Resum

Multiple sclerosis is the most frequent disabling neurological disease in young adults. Its development includes independent processes of inflammation, demyelination, neurodegeneration, gliosis and repair, which are responsible for the heterogeneity and individual variability in the expression of the disease, its prognosis and response to treatment. As part of personalised medicine, the progress made in the search for new biomarkers has identified promising candidates that may be useful for the early diagnosis of the disease, for detecting prognostic and developmental profiles of the disease, and for monitoring the response to treatment. Unfortunately, few of them have been validated adequately, which prevents them from being applied in clinical practice. In view of the latest findings, the experts recommend orienting research in another direction, not so much towards the discovery of new molecules or imaging techniques, but instead towards a clinical validation of these markers, with the aim of fostering translational research. This review offers an update on the information about the biomarkers in multiple sclerosis that have currently been validated and are thus potential candidates, as well as looking at their value in the diagnosis, prognosis, evaluation of the development of the disability caused by the disease and the response to therapy.
Títol traduït de la contribucióBiomarkers in multiple sclerosis
Idioma originalEspanyol
Pàgines (de-a)375-390
Nombre de pàgines16
RevistaRevista de neurologia
Volum56
Número7
DOIs
Estat de la publicacióPublicada - 1 d’abr. 2013

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