TY - JOUR
T1 - Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural β-carboline canthin-6-one
AU - Doménech-Carbó, Antonio
AU - Rodrigo, Regina
AU - Maréchal, Jean Didier
AU - Poupon, Erwan
AU - Fournet, Alain
AU - Figadère, Bruno
AU - Cebrián-Torrejón, Gerardo
PY - 2017/4/15
Y1 - 2017/4/15
N2 - © 2016 Elsevier B.V. The inhibition of soluble guanylate cyclase (sGC) by canthin-6-one alkaloid (L1) is presented and the mechanism of deactivation is studied using solution phase and voltammetry of microparticles methodologies. Possible inhibition pathways: oxidation of Fe2+ to Fe3+ coupled to reduction of the naphthyridone motif present by the canthin-6-one and coordinating or reacting of L1 with cysteine units of sGC, are balanced.
AB - © 2016 Elsevier B.V. The inhibition of soluble guanylate cyclase (sGC) by canthin-6-one alkaloid (L1) is presented and the mechanism of deactivation is studied using solution phase and voltammetry of microparticles methodologies. Possible inhibition pathways: oxidation of Fe2+ to Fe3+ coupled to reduction of the naphthyridone motif present by the canthin-6-one and coordinating or reacting of L1 with cysteine units of sGC, are balanced.
U2 - 10.1016/j.molstruc.2016.12.016
DO - 10.1016/j.molstruc.2016.12.016
M3 - Article
SN - 0022-2860
VL - 1134
SP - 661
EP - 667
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
ER -