Biochemical differences between products of the Adh locus in Drosophila

Mauro Santos, John F McDonald

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Resum

An analysis of the molecular properties of the major alcohol dehydrogenase
(E.C.1.1.1.1) allozyme variants found segregating in natural populations of
D. mehnogaster is presented. Our results indicate: (1) ADH-S enzyme has
generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S
and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype.
The possible adaptive significance of these findings is discussed.
Idioma originalAnglès
Pàgines (de-a)1013-1022
Nombre de pàgines10
RevistaGenetics
Volum95
Estat de la publicacióPublicada - d’ag. 1980

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