Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas; Alexandr Shafir; Adelina Vallribera

doi:10.1021/ol400136y

Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas, Alexandr Shafir, Adelina Vallribera

Departament de Química

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Resum

A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.

Idioma original	Anglès
Pàgines (de-a)	1448-1451
Revista	Organic Letters
Volum	15
Número	7
DOIs	https://doi.org/10.1021/ol400136y
Estat de la publicació	Publicada - 5 d’abr. 2013

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10.1021/ol400136y

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title = "Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination",

abstract = "A stereoselective synthesis of l-carbidopa in seven steps and 50\% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. {\textcopyright} 2013 American Chemical Society.",

author = "Lex Pericas and Alexandr Shafir and Adelina Vallribera",

year = "2013",

month = apr,

day = "5",

doi = "10.1021/ol400136y",

language = "English",

volume = "15",

pages = "1448--1451",

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TY - JOUR

T1 - Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

AU - Pericas, Lex

AU - Shafir, Alexandr

AU - Vallribera, Adelina

PY - 2013/4/5

Y1 - 2013/4/5

N2 - A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.

AB - A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.

UR - https://www.scopus.com/pages/publications/84875924791

U2 - 10.1021/ol400136y

DO - 10.1021/ol400136y

M3 - Article

SN - 1523-7060

VL - 15

SP - 1448

EP - 1451

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

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