Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas, Alexandr Shafir, Adelina Vallribera

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Resum

A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.
Idioma originalAnglès
Pàgines (de-a)1448-1451
RevistaOrganic Letters
Volum15
Número7
DOIs
Estat de la publicacióPublicada - 5 d’abr. 2013

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