Resum
A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.
Idioma original | Anglès |
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Pàgines (de-a) | 1448-1451 |
Revista | Organic Letters |
Volum | 15 |
Número | 7 |
DOIs | |
Estat de la publicació | Publicada - 5 d’abr. 2013 |