Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase

Xavier Garrabou; José A. Castillo; Christine Guérard-Hélaine; Teodor Parella; Jesús Joglar; Marielle Lemaire; Pere Clapés

doi:10.1002/anie.200902065

Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase

Xavier Garrabou, José A. Castillo, Christine Guérard-Hélaine, Teodor Parella, Jesús Joglar, Marielle Lemaire, Pere Clapés

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New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Idioma original	Anglès
Pàgines (de-a)	5521-5525
Revista	Angewandte Chemie - International Edition
Volum	48
Número	30
DOIs	https://doi.org/10.1002/anie.200902065
Estat de la publicació	Publicada - 13 de jul. 2009

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10.1002/anie.200902065

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@article{52f8d1f7e67a421a9969293110d96296,

title = "Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase",

abstract = "New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low. {\textcopyright} 2009 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Aldol reaction, Aldolases, Aldoses, Enzyme catalysis, Glycolaldehydes",

author = "Xavier Garrabou and Castillo, {Jos{\'e} A.} and Christine Gu{\'e}rard-H{\'e}laine and Teodor Parella and Jes{\'u}s Joglar and Marielle Lemaire and Pere Clap{\'e}s",

year = "2009",

month = jul,

day = "13",

doi = "10.1002/anie.200902065",

language = "English",

volume = "48",

pages = "5521--5525",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "30",

}

Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase. / Garrabou, Xavier; Castillo, José A.; Guérard-Hélaine, Christine et al.
In: Angewandte Chemie - International Edition, Vol. 48, Núm. 30, 13.07.2009, pàg. 5521-5525.

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase

AU - Garrabou, Xavier

AU - Castillo, José A.

AU - Guérard-Hélaine, Christine

AU - Parella, Teodor

AU - Joglar, Jesús

AU - Lemaire, Marielle

AU - Clapés, Pere

PY - 2009/7/13

Y1 - 2009/7/13

N2 - New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Aldol reaction

KW - Aldolases

KW - Aldoses

KW - Enzyme catalysis

KW - Glycolaldehydes

U2 - 10.1002/anie.200902065

DO - 10.1002/anie.200902065

M3 - Article

SN - 1433-7851

VL - 48

SP - 5521

EP - 5525

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 30

ER -

Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by d-fructose-6-phosphate aldolase

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