Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Anna Hernández-Rubio, Arantza Sanvisens, Lucía Barbier-Torres, Rafael Blanes, Laia Miquel, Marta Torrens, Gabriel Rubio, Ferran Bolao, Paola Zuluaga, Daniel Fuster, Fernando Rodríguez de Fonseca, Magí Farré, Robert Muga*, Esther Papasseit, Clara Pérez-Mañá, Lourdes Poyatos, Nuria García-Marchena, Enric Abellí, Antonio Short, Catalina MorantaAna Sion, Lluisa Ortega, Pol Bruguera, Elsa Caballeria, Ana Messeguer, Francina Fonseca, Juan Ignacio Mestre-Pinto, María Alías, Fernando Dinamarca, Francisco Javier Pavón-Morón, Pedro Araos, María Flores-López, Antonia Serrano, Miguel Marcos, Candelaria Martín, Onán Pérez-Hernández, Jorge Manzanares, Lucía Illescas

*Autor corresponent d’aquest treball

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INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.

PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.

RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.

CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

Idioma originalEnglish
Número d’article109822
Pàgines (de-a)109822
Nombre de pàgines7
RevistaDrug Alcohol Depend
Volum245
DOIs
Estat de la publicacióPublicada - 1 d’abr. 2023

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