TY - JOUR
T1 - Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline :
T2 - Fundació ACE Healthy Brain Initiative
AU - Marquié, Marta
AU - Valero, Sergi
AU - Castilla Marti, Miguel
AU - Martínez, Joan
AU - Rodríguez-Gómez, Octavio
AU - Sanabria, Ángela
AU - Tartari, Juan Pablo
AU - Monté-Rubio, Gemma C.
AU - Sotolongo Grau, Oscar
AU - Alegret, Montserrat
AU - Pérez-Cordón, Alba
AU - Roberto, Natalia
AU - De Rojas, Itziar
AU - Moreno-Grau, Sonia
AU - Montrreal, Laura
AU - Hernández, Isabel
AU - Rosende-Roca, Maitée
AU - Mauleón, Ana
AU - Vargas, Liliana
AU - Abdelnour, Carla
AU - Gil-Navarro, Silvia
AU - Esteban de Antonio, Ester
AU - Espinosa, Ana
AU - Ortega, Gemma
AU - Lomeña, Francisco
AU - Pavia, Javier
AU - Vivas, Assumpta
AU - Tejero, Miguel Ángel
AU - Gómez-Chiari, Marta
AU - Simó Canonge, Rafael
AU - Ciudin, Andreea
AU - Hernández, Cristina
AU - Orellana, Adelina
AU - Benaque, Alba
AU - Ruiz, Agustín
AU - Tárraga, Lluís
AU - Boada, Mercè
PY - 2020
Y1 - 2020
N2 - Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake. We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/−) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Mean age of the sample was 64.72 ± 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 μm of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02-1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: β = 0.23, p = 0.004; at v2: β = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Subtle retinal thickness changes in the macular region are already present in SCD and correlate with Aβ uptake.
AB - Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake. We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/−) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Mean age of the sample was 64.72 ± 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 μm of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02-1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: β = 0.23, p = 0.004; at v2: β = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Subtle retinal thickness changes in the macular region are already present in SCD and correlate with Aβ uptake.
KW - Optical coherence tomography
KW - Retinal thickness
KW - Subjective cognitive decline
KW - β-Amyloid
KW - Florbetaben
KW - Positron emission tomography
U2 - 10.1186/s13195-020-00602-9
DO - 10.1186/s13195-020-00602-9
M3 - Article
C2 - 32234080
SN - 1758-9193
VL - 12
JO - Alzheimer's Research and Therapy
JF - Alzheimer's Research and Therapy
ER -