TY - JOUR
T1 - Antifungal sesquiterpene from the root of Vernonanthura tweedieana
AU - Portillo, Aida
AU - Vila, Roser
AU - Freixa, Blanca
AU - Ferro, Esteban
AU - Parella, Teodor
AU - Casanova, Joseph
AU - Cañigueral, Salvador
PY - 2005/2/10
Y1 - 2005/2/10
N2 - The bioassay-guided fractionation of the antifungal dichloromethane extract from the roots of Vernonanthura tweedieana (Baker) H. Rob. (Asteraceae), using an agar overlay bioautographic method, allowed the isolation of one active sesquiterpene (1), identified as 6-cinnamoyloxy-1-hydroxyeudesm-4-en-3-one. Minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) of 1 showed Trichophyton mentagrophytes as the most sensitive strain, with the same MIC and MFC values (4 μg/ml). © 2004 Elsevier Ireland Ltd. All rights reserved.
AB - The bioassay-guided fractionation of the antifungal dichloromethane extract from the roots of Vernonanthura tweedieana (Baker) H. Rob. (Asteraceae), using an agar overlay bioautographic method, allowed the isolation of one active sesquiterpene (1), identified as 6-cinnamoyloxy-1-hydroxyeudesm-4-en-3-one. Minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) of 1 showed Trichophyton mentagrophytes as the most sensitive strain, with the same MIC and MFC values (4 μg/ml). © 2004 Elsevier Ireland Ltd. All rights reserved.
KW - 6-Cinnamoyloxy-1-hydroxyeudesm-4-en-3-one
KW - Antifungal activity
KW - Asteraceae
KW - Bioguided fractionation
KW - Vernonanthura tweedieana
U2 - 10.1016/j.jep.2004.09.052
DO - 10.1016/j.jep.2004.09.052
M3 - Article
SN - 0378-8741
VL - 97
SP - 49
EP - 52
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
ER -