Anti-inflammatory Cotton Fabrics and Silica Nanoparticles with Potential Topical Medical Applications

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

21 Cites (Scopus)
1 Descàrregues (Pure)

Resum

The preparation of functional cotton fabrics and silica nanoparticles by direct covalent linking of nonsteroidal anti-inflammatory drugs (salicylic acid, ibuprofen, and diclofenac) through an amide group is reported. Moreover, the coating of cotton fabrics with silica nanoparticles functionalized with such antiinflamatory agents is found to increase the roughness of the surface, providing hydrophobicity to the modified fabrics. This property is enhanced by the addition of fluorinated alkyl silane in the co-condensation process to form the coating solution. Characterization of the functionalized nanoparticles and cotton textiles is accomplished by microscopic and spectroscopic techniques. The treatment of functionalized nanoparticles and cotton fabrics with model proteases and leukocytes from animal origin results in the in situ release of the drug by the selective enzymatic cleavage of the amide bond. Topical cutaneous applications in wound dressings and cream formulations for the acceleration of wound healing are envisaged.
Idioma originalEnglish
Pàgines (de-a)25658
Nombre de pàgines25675
RevistaACS Applied Materials & Interfaces
Volum12
Número23
DOIs
Estat de la publicacióPublicada - 10 de juny 2020

Fingerprint

Navegar pels temes de recerca de 'Anti-inflammatory Cotton Fabrics and Silica Nanoparticles with Potential Topical Medical Applications'. Junts formen un fingerprint únic.

Com citar-ho