TY - JOUR
T1 - Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw
AU - Romero, Asunción
AU - Planas, Eulalia
AU - Poveda, Raquel
AU - Sánchez, Silvia
AU - Pol, Olga
AU - Puig, Margarita M.
N1 - Funding Information:
The authors thank Ms. Salud Sánchez for her technical assistance. This work was partially supported by grants from Fundació La Marató de TV3 no. 2032/97; no. 2132/97 and Generalitat de Catalunya no. 2001SRG00409, Barcelona, Spain.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/3/28
Y1 - 2005/3/28
N2 - We evaluated the anti-exudative effects (Evan's blue) of mu-, delta- and kappa-opioid receptor agonists in a rat model of carrageenan-induced acute inflammation. The contribution of different components was assessed after the administration of: cyclosporine A, capsaicin, 6-hydroxydopamine, compound 48/80, and specific histamine-receptor antagonists. The results show that the mu-opioid receptor agonists morphine and fentanyl and the delta-opioid receptor agonists DPDPE (enkephalin, [d-Pen2,5]) and SNC 80 ((+)-4-[(αR)-α((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl) -3-methoxybenzyl]-N,N diethylbenzamide) decrease plasma extravasation in a dose-dependent manner, with a biphasic response. The effects were reversed by specific antagonists, and are predominantly mediated by peripheral opioid receptors. The integrity of sensory and sympathetic fibres is essential for the anti-exudative effects of fentanyl and DPDPE. Histamine and functional histamine H2 and H3 receptors are required for morphine and fentanyl (but not DPDPE) inhibition of plasma extravasation, suggesting different mechanism for mu- and delta-opioid receptor agonists. The present findings implicate multiple sites and mechanisms in the anti-exudative effects of exogenous opioids.
AB - We evaluated the anti-exudative effects (Evan's blue) of mu-, delta- and kappa-opioid receptor agonists in a rat model of carrageenan-induced acute inflammation. The contribution of different components was assessed after the administration of: cyclosporine A, capsaicin, 6-hydroxydopamine, compound 48/80, and specific histamine-receptor antagonists. The results show that the mu-opioid receptor agonists morphine and fentanyl and the delta-opioid receptor agonists DPDPE (enkephalin, [d-Pen2,5]) and SNC 80 ((+)-4-[(αR)-α((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl) -3-methoxybenzyl]-N,N diethylbenzamide) decrease plasma extravasation in a dose-dependent manner, with a biphasic response. The effects were reversed by specific antagonists, and are predominantly mediated by peripheral opioid receptors. The integrity of sensory and sympathetic fibres is essential for the anti-exudative effects of fentanyl and DPDPE. Histamine and functional histamine H2 and H3 receptors are required for morphine and fentanyl (but not DPDPE) inhibition of plasma extravasation, suggesting different mechanism for mu- and delta-opioid receptor agonists. The present findings implicate multiple sites and mechanisms in the anti-exudative effects of exogenous opioids.
KW - Histamine
KW - Inflammation
KW - Oedema
KW - Opioid receptor
KW - Plasma extravasation
UR - http://www.scopus.com/inward/record.url?scp=15844414166&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2005.02.004
DO - 10.1016/j.ejphar.2005.02.004
M3 - Article
C2 - 15792790
SN - 0014-2999
VL - 511
SP - 207
EP - 217
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -