TY - JOUR
T1 - Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units
AU - Lorente, Victòria
AU - Aboal, Jaime
AU - Garcia, Cosme
AU - Sans-Roselló, Jordi
AU - Sambola, Antonia
AU - Andrea, Rut
AU - Tomás, Carlos
AU - Bonet, Gil
AU - Viñas, David
AU - Ouaddi, Nabil el
AU - Montero, Santiago
AU - Cantalapiedra, Javier
AU - Pujol, Margarida
AU - Hernández, Isabel
AU - Pérez-Rodriguez, María
AU - Llaó, Isaac
AU - Sánchez-Salado, José C.
AU - Gual, Miquel
AU - Ariza-Solé, Albert
N1 - Publisher Copyright:
© 2020 JGC All rights reserved
PY - 2020/1
Y1 - 2020/1
N2 - Background Little information exists about the role of anemia in patients with acute coronary syndromes (ACS) admitted to Intensive Cardiac Care Units (ICCU). The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting. Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS (NSTEACS) were prospectively included. Anemia was defined as hemoglobin < 130 g/L in men and < 120 g/L in women. The association between anemia and mortality or readmission at six months was assessed by the Cox regression method. Results A total of 629 patients were included. Mean age was 66.6 years. A total of 197 patients (31.3%) had anemia. Coronary angiography was performed in most patients (96.2%). Patients with anemia were significantly older, with a higher prevalence of comorbidities, poorer left ventricle ejection fraction and higher GRACE score values. Patients with anemia underwent less often coronary angiography, but underwent more often intraaortic counterpulsation, non-invasive mechanical ventilation and renal replacement therapies. Both ICCU and hospital stay were significantly longer in patients with anemia. Both the incidence of mortality (HR = 3.36, 95% CI: 1.43-7.85, P = 0.001) and the incidence of mortality/readmission were significantly higher in patients with anemia (HR = 2.80, 95% CI: 2.03-3.86, P = 0.001). After adjusting for confounders, the association between anemia and mortality/readmission remained significant (P = 0.031). Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia. Most patients underwent coronary angiography. Anemia was independently associated to poorer outcomes at 6 months.
AB - Background Little information exists about the role of anemia in patients with acute coronary syndromes (ACS) admitted to Intensive Cardiac Care Units (ICCU). The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting. Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS (NSTEACS) were prospectively included. Anemia was defined as hemoglobin < 130 g/L in men and < 120 g/L in women. The association between anemia and mortality or readmission at six months was assessed by the Cox regression method. Results A total of 629 patients were included. Mean age was 66.6 years. A total of 197 patients (31.3%) had anemia. Coronary angiography was performed in most patients (96.2%). Patients with anemia were significantly older, with a higher prevalence of comorbidities, poorer left ventricle ejection fraction and higher GRACE score values. Patients with anemia underwent less often coronary angiography, but underwent more often intraaortic counterpulsation, non-invasive mechanical ventilation and renal replacement therapies. Both ICCU and hospital stay were significantly longer in patients with anemia. Both the incidence of mortality (HR = 3.36, 95% CI: 1.43-7.85, P = 0.001) and the incidence of mortality/readmission were significantly higher in patients with anemia (HR = 2.80, 95% CI: 2.03-3.86, P = 0.001). After adjusting for confounders, the association between anemia and mortality/readmission remained significant (P = 0.031). Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia. Most patients underwent coronary angiography. Anemia was independently associated to poorer outcomes at 6 months.
KW - Acute coronary syndromes
KW - Anemia
KW - Intensive cardiac care units
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85087845145&partnerID=8YFLogxK
U2 - 10.11909/j.issn.1671-5411.2020.01.006
DO - 10.11909/j.issn.1671-5411.2020.01.006
M3 - Article
C2 - 32133035
AN - SCOPUS:85087845145
SN - 1671-5411
VL - 17
SP - 35
EP - 42
JO - Journal of Geriatric Cardiology
JF - Journal of Geriatric Cardiology
IS - 1
ER -