TY - JOUR
T1 - Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design
AU - Boix, Ester
AU - Li, Jiarui
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/8
Y1 - 2024/8
N2 - The dynamics behavior of a protein is essential for its functionality. Here, Doucet et al. demonstrate how the evolutionary analysis of conformational pathways within a protein family serves to identify common core scaffolds that accommodate branch-specific functional regions controlled by flexibility switches, offering a model for evolutionary-dynamics based protein design
AB - The dynamics behavior of a protein is essential for its functionality. Here, Doucet et al. demonstrate how the evolutionary analysis of conformational pathways within a protein family serves to identify common core scaffolds that accommodate branch-specific functional regions controlled by flexibility switches, offering a model for evolutionary-dynamics based protein design
KW - Evolution, Molecular
KW - Models, Molecular
KW - Protein Conformation
KW - Protein Engineering
KW - Ribonucleases/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85195879128&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/982b17e6-4337-342d-a4fc-46d1cc590787/
U2 - 10.1016/j.tibs.2024.06.005
DO - 10.1016/j.tibs.2024.06.005
M3 - Article
C2 - 38880687
SN - 0376-5067
VL - 49
SP - 660
EP - 662
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -