An effective enantioselective approach to the securinega alkaloids: Total synthesis of (-)-norsecurinine

Ramón Alibés, Pau Bayón, Pedro De March, Marta Figueredo, Josep Font, Elena García-García, David González-Gálvez

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Resum

(Chemical Equation Presented) A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield. © 2005 American Chemical Society.
Idioma originalAnglès
Pàgines (de-a)5107-5109
RevistaOrganic Letters
Volum7
Número22
DOIs
Estat de la publicacióPublicada - 27 d’oct. 2005

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