@article{b67d7e041cb04eda8c58d2051fff2313,
title = "An association analysis for 14 candidate genes mapping to meat quality quantitative trait loci in a Duroc pig population reveals that the ATP1A2 genotype is highly associated with muscle electric conductivity",
abstract = "In previous GWAS carried out in a Duroc commercial line (Lipgen population), we detected on pig chromosomes 3, 4 and 14 several QTL for gluteus medius muscle redness (GM a*), electric conductivity in the longissimus dorsi muscle (LD CE) and vaccenic acid content in the LD muscle (LD C18:1 n − 7), respectively. We have genotyped, in the Lipgen population, 19 SNPs mapping to 14 genes located within these QTL. Subsequently, association analyses have been performed. After correction for multiple testing, two SNPs in the TGFBRAP1 (rs321173745) and SELENOI (rs330820437) genes were associated with GM a*, whereas ACADSB (rs81449951) and GPR26 (rs343087568) genotypes displayed significant associations with LD vaccenic content. Moreover, the polymorphisms located at the ATP1A2 (rs344748241), ATP8B2 (rs81382410) and CREB3L4 (rs321278469 and rs330133789) genes showed significant associations with LD CE. We made a second round of association analyses including the SNPs mentioned above as well as other SNPs located in the chromosomes to which they map. After performing a correction for multiple testing, the only association that remained significant at the chromosome-wide level was that between the ATP1A2 genotype and LD CE. From a functional point of view, this association is meaningful because this locus encodes a subunit of the Na+/K+-ATPase responsible for maintaining an electrochemical gradient across the plasma membrane.",
keywords = "Na/K-ATPase, pig, single nucleotide polymorphism",
author = "E. M{\'a}rmol-S{\'a}nchez and R. Quintanilla and J. Jordana and M. Amills",
note = "Funding Information: E. M{\'a}rmol‐S{\'a}nchez R. Quintanilla J. Jordana M. Amills
[email protected] Department of Animal Genetics Centre for Research in Agricultural Genomics CSIC‐IRTA‐UAB‐UB Universitat Aut{\`o}noma de Barcelona Bellaterra 08193 Spain Animal Breeding and Genetics Program Institute for Research and Technology in Food and Agriculture (IRTA), Torre Marimon Caldes de Montbui 08140 Spain Departament de Ci{\`e}ncia Animal i dels Aliments Universitat Aut{\`o}noma de Barcelona Bellaterra 08193 Spain Na + /K + ‐ ATP ase pig single nucleotide polymorphism Spanish Ministry of Economy and Competitiveness AGL2013‐48742‐C2‐1‐R AGL2013‐48742‐C2‐2‐R Agency for Management of University and Research Grants of the Generalitat de Catalunya 2014 SGR 1528 Spanish Ministry of Education FPU15/01733 Spanish Ministry of Economy and Competitiveness for the Center of Excellence Severo Ochoa 2016–2019 SEV‐2015‐0533 Table S1 Additional information about selected SNP and their potential impact and deleteriousness (SIFT). Figure S1 Graph depicting the magnitude of linkage disequilibrium among SNPs that showed significant associations with longissimus dorsi electric conductivity after correction for multiple testing at the chromosome‐wide level. Funding Information: The authors are indebted to Selecci{\'o} Batall{\'e} S.A. for providing the animal material used in this study. We gratefully acknowledge J. Reixach and J. Soler (IRTA) for their collaboration in the experimental protocols. This research was partially funded with grants AGL2013‐48742‐C2‐1‐R and AGL2013‐48742‐C2‐2‐R awarded by the Spanish Ministry of Economy and Competitiveness and grant 2014 SGR 1528 from the Agency for Management of University and Research Grants of the Generalitat de Catalunya. Emilio M{\'a}rmol‐S{\'a}nchez was funded with an FPU PhD grant from the Spanish Ministry of Education (FPU15/01733). We also acknowledge the support of the Spanish Ministry of Economy and Competitiveness for the Center of Excellence Severo Ochoa 2016–2019 (SEV‐2015‐0533) grant awarded to the Center for Research in Agricultural Genomics. Thanks also to the CERCA Programme of the Generalitat de Catalunya. Publisher Copyright: {\textcopyright} 2019 Stichting International Foundation for Animal Genetics Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = feb,
day = "1",
doi = "10.1111/age.12864",
language = "Ingl{\'e}s estadounidense",
volume = "51",
pages = "95--100",
journal = "Animal Genetics",
issn = "0268-9146",
number = "1",
}