TY - JOUR
T1 - Altered slow (<1 Hz) and fast (beta and gamma) neocortical oscillations in the 3xTg-AD mouse model of Alzheimer's disease under anesthesia
AU - Perez-Mendez, Lorena
AU - Giménez-Llort, Lydia
AU - Perez-Zabalza, Maria
AU - Sanchez-Vives, Maria V.
AU - Castano-Prat, Patricia
AU - Sanfeliu, Coral
PY - 2019/7/1
Y1 - 2019/7/1
N2 - © 2019 The Authors The 3xTg-AD mouse model reproduces the main features associated with the etiology of familial Alzheimer's disease (AD). To investigate whether these features imply functional cortical network alterations and their evolution with age, we studied spontaneous slow oscillations, activity that integrates cellular and network properties. We quantified different parameters of the emergent slow oscillations—alternating Up and Down states—and of the embedded beta-gamma rhythms of 3xTg-AD and wild-type mice at 7 and 20 months of age. Most group differences occurred at 20 months of age: 3xTg-AD mice presented lower oscillatory frequency, higher cycle variability, and reduced relative (Up/Down) firing rate with respect to controls. The high-frequency analysis revealed a shift toward lower frequencies in older 3xTg-AD animals, reminiscent of one of the electroencephalography hallmarks of patients with AD. This first systematic characterization of the cortical emergent rhythms in 3xTg-AD strain provides insights into the network mechanisms underlying associated network activity alterations.
AB - © 2019 The Authors The 3xTg-AD mouse model reproduces the main features associated with the etiology of familial Alzheimer's disease (AD). To investigate whether these features imply functional cortical network alterations and their evolution with age, we studied spontaneous slow oscillations, activity that integrates cellular and network properties. We quantified different parameters of the emergent slow oscillations—alternating Up and Down states—and of the embedded beta-gamma rhythms of 3xTg-AD and wild-type mice at 7 and 20 months of age. Most group differences occurred at 20 months of age: 3xTg-AD mice presented lower oscillatory frequency, higher cycle variability, and reduced relative (Up/Down) firing rate with respect to controls. The high-frequency analysis revealed a shift toward lower frequencies in older 3xTg-AD animals, reminiscent of one of the electroencephalography hallmarks of patients with AD. This first systematic characterization of the cortical emergent rhythms in 3xTg-AD strain provides insights into the network mechanisms underlying associated network activity alterations.
KW - Cerebral cortex
KW - Alzheimer disease
KW - Transgenic model
KW - Gamma rhythm
KW - Up states
KW - Aging
KW - Excitability
KW - Slow oscillations
KW - Gamma oscillations
U2 - 10.1016/j.neurobiolaging.2019.02.009
DO - 10.1016/j.neurobiolaging.2019.02.009
M3 - Article
C2 - 31103943
SN - 0197-4580
VL - 79
SP - 142
EP - 151
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -