Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold :: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

Rafael Simó Canonge; Ibane Abasolo; Patricia Gutiérrez-Carcedo; Sergio Navalón; Xavier Setoain; Carolina Aparicio-Gómez; Victor Manuel Victor; Hermenegildo García

doi:10.3390/nano10040744

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold : An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

Rafael Simó Canonge, Ibane Abasolo, Patricia Gutiérrez-Carcedo, Sergio Navalón, Xavier Setoain, Carolina Aparicio-Gómez, Victor Manuel Victor, Hermenegildo García

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

17 Cites (Scopus)

Resum

Les nanopartícules de cèria són antioxidants compatibles amb les cèl·lules l'activitat es pot potenciar mitjançant la deposició d'or i la funcionalització superficial amb unitats positives de trifenilfosfoni per a dirigir-se selectivament als mitocondris. Les propietats antioxidatives d'aquestes nanopartícules poden servir com a base d'una nova estratègia pel tractament de diverses malalties que mostren estrès oxidatiu, com ara el càncer, la diabetis o l'Alzheimer. Tot i això, totes aquestes patologies requereixen un antioxidant específic segons el seu mecanisme per eliminar l'excés d'espècies oxidatives en les cèl·lules i disminuir-ne els efectes sobre la funció mitocondrial. El mecanisme a través del qual les nanopartícules de cèria neutralitzen l'estrès oxidatiu i el seu efecte sobre la funció mitocondrial encara no s'ha caracteritzat. En aquest estudi, es va avaluar l'efecte antioxidant en els mitocondris de les cèl·lules HeLa de les nanopartícules de ceria i d'or amb o sense funcionalització de trifenilfosfoni, amb producció d'adenosina triphosphat (ATP), factor respiratori nuclear 1 (NRF1) i factor erythroid-2 similar al nucleòtid 1 (NFE2L1). Aquest efecte es va revertir per la presència d'or. A més a més, aquest efecte es va potenciar quan les nanopartícules es van funcionalitzar amb trifenilfosfoni. El nostre estudi il·lustra com l'efecte antioxidant mitocondrial induït per les nanopartícules de cèria pot ser modulat per la presència d'or

Idioma original	Anglès
Revista	Nanomaterials
Volum	10
DOIs	https://doi.org/10.3390/nano10040744
Estat de la publicació	Publicada - 2020

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

ODG 3 – Bona salut i benestar

Accés al document

10.3390/nano10040744

https://ddd.uab.cat/record/252560

Altres arxius i enllaços

https://www.scopus.com/pages/publications/85083716186

Com citar-ho

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title = "Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold :: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine",

abstract = "Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer's disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (∆Ψm), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid-2-like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold",

keywords = "Mitochondrial function, Ceria nanoparticles, Gold-supported ceria nanoparticles, Antioxidant, Triphenylphosphonium gold-supported ceria nanoparticles",

author = "\{Sim{\'o} Canonge\}, Rafael and Ibane Abasolo and Patricia Guti{\'e}rrez-Carcedo and Sergio Naval{\'o}n and Xavier Setoain and Carolina Aparicio-G{\'o}mez and Victor, \{Victor Manuel\} and Hermenegildo Garc{\'i}a",

year = "2020",

doi = "10.3390/nano10040744",

language = "English",

volume = "10",

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TY - JOUR

T1 - Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold :

T2 - An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

AU - Simó Canonge, Rafael

AU - Abasolo, Ibane

AU - Gutiérrez-Carcedo, Patricia

AU - Navalón, Sergio

AU - Setoain, Xavier

AU - Aparicio-Gómez, Carolina

AU - Victor, Victor Manuel

AU - García, Hermenegildo

PY - 2020

Y1 - 2020

N2 - Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer's disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (∆Ψm), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid-2-like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold

AB - Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer's disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (∆Ψm), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid-2-like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold

KW - Mitochondrial function

KW - Ceria nanoparticles

KW - Gold-supported ceria nanoparticles

KW - Antioxidant

KW - Triphenylphosphonium gold-supported ceria nanoparticles

UR - https://www.scopus.com/pages/publications/85083716186

U2 - 10.3390/nano10040744

DO - 10.3390/nano10040744

M3 - Article

C2 - 32295053

SN - 2079-4991

VL - 10

JO - Nanomaterials

JF - Nanomaterials