TY - JOUR
T1 - Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
AU - Roldan, Elisa
AU - Perales, Miguel Angel
AU - Barba, Pere
PY - 2019
Y1 - 2019
N2 - The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.
AB - The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.
KW - Allogeneic transplant
KW - Graft- versus -host disease
KW - T cell depletion
KW - CD34+ cell selection
KW - Graft- versus -host disease-free and relapse-free survival (GRFS)
U2 - 10.2991/chi.d.190613.001
DO - 10.2991/chi.d.190613.001
M3 - Review article
C2 - 34595425
SN - 2590-0048
VL - 1
SP - 154
EP - 160
JO - Clinical Hematology International
JF - Clinical Hematology International
IS - 3
ER -