TY - JOUR
T1 - Advanced interatrial block predicts new-onset atrial fibrillation and ischemic stroke in patients with heart failure: The “Bayes' Syndrome-HF” study
AU - Escobar-Robledo, Luis Alberto
AU - Bayés-de-Luna, Antoni
AU - Lupón, Josep
AU - Baranchuk, Adrian
AU - Moliner, Pedro
AU - Martínez-Sellés, Manuel
AU - Zamora, Elisabet
AU - de Antonio, Marta
AU - Domingo, Mar
AU - Cediel, Germán
AU - Núñez, Julio
AU - Santiago-Vacas, Evelyn
AU - Bayés-Genís, Antoni
PY - 2018/11/15
Y1 - 2018/11/15
N2 - © 2018 Elsevier B.V. Aims: Advanced interatrial block (IAB) is characterized by a prolonged (≥120 ms) and bimodal P wave in the inferior leads. The association between advanced IAB and atrial fibrillation (AF) is known as “Bayes' Syndrome”, and there is scarce information about it in heart failure (HF). We examined the prevalence of IAB and whether advanced IAB could predict new-onset AF and/or stroke in HF patients. Methods and results: The prospective observational “Bayes' Syndrome-HF” study included consecutive outpatients with chronic HF. The primary endpoints were new-onset AF, ischemic stroke, and the composite of both. A secondary endpoint included all-cause death alone or in combination with the primary endpoint. Comprehensive multivariable Cox regression analyses were performed. Among 1050 consecutive patients, 536 (51.0%) were in sinus rhythm, 464 with a measurable P wave are the focus of this study. Two-hundred and sixty patients (56.0%) had normal atrial conduction, 95 (20.5%) partial IAB, and 109 (23.5%) advanced IAB. During a mean follow-up of 4.5 ± 2.1 years, 235 patients experienced all-cause death, new-onset AF, or stroke. In multivariable comprehensive Cox regression analyses, advanced IAB was associated with new-onset AF (HR 2.71 [1.61–4.56], P < 0.001), ischemic stroke (HR 3.02 [1.07–8.53], P = 0.04), and the composite of both (HR 2.42 [1.41–4.15], P < 0.001). Conclusions: In patients with HF advanced IAB predicts new-onset AF and ischemic stroke. Future studies must assess whether anticoagulant treatment in Bayes' Syndrome leads to better outcomes in HF.
AB - © 2018 Elsevier B.V. Aims: Advanced interatrial block (IAB) is characterized by a prolonged (≥120 ms) and bimodal P wave in the inferior leads. The association between advanced IAB and atrial fibrillation (AF) is known as “Bayes' Syndrome”, and there is scarce information about it in heart failure (HF). We examined the prevalence of IAB and whether advanced IAB could predict new-onset AF and/or stroke in HF patients. Methods and results: The prospective observational “Bayes' Syndrome-HF” study included consecutive outpatients with chronic HF. The primary endpoints were new-onset AF, ischemic stroke, and the composite of both. A secondary endpoint included all-cause death alone or in combination with the primary endpoint. Comprehensive multivariable Cox regression analyses were performed. Among 1050 consecutive patients, 536 (51.0%) were in sinus rhythm, 464 with a measurable P wave are the focus of this study. Two-hundred and sixty patients (56.0%) had normal atrial conduction, 95 (20.5%) partial IAB, and 109 (23.5%) advanced IAB. During a mean follow-up of 4.5 ± 2.1 years, 235 patients experienced all-cause death, new-onset AF, or stroke. In multivariable comprehensive Cox regression analyses, advanced IAB was associated with new-onset AF (HR 2.71 [1.61–4.56], P < 0.001), ischemic stroke (HR 3.02 [1.07–8.53], P = 0.04), and the composite of both (HR 2.42 [1.41–4.15], P < 0.001). Conclusions: In patients with HF advanced IAB predicts new-onset AF and ischemic stroke. Future studies must assess whether anticoagulant treatment in Bayes' Syndrome leads to better outcomes in HF.
KW - Advanced interatrial block
KW - All-cause death
KW - Heart failure
KW - New-onset atrial fibrillation
KW - Stroke
U2 - 10.1016/j.ijcard.2018.05.050
DO - 10.1016/j.ijcard.2018.05.050
M3 - Article
C2 - 29801761
SN - 0167-5273
VL - 271
SP - 174
EP - 180
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -