Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children

A. Martinez-Roig; J. Cami; J. Llorens-Terol; R. de la Torre; F. Perich

Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children

A. Martinez-Roig, J. Cami, J. Llorens-Terol, R. de la Torre, F. Perich

Departament de Pediatria, d’Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

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Resum

We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.

Idioma original	Anglès
Pàgines (de-a)	912-915
Revista	Pediatrics
Volum	77
Número	6
Estat de la publicació	Publicada - 24 de set. 1986

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@article{37839dd0b31d48b1b5c4c8b3f464c086,

title = "Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children",

abstract = "We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.",

author = "A. Martinez-Roig and J. Cami and J. Llorens-Terol and {de la Torre}, R. and F. Perich",

year = "1986",

month = sep,

day = "24",

language = "English",

volume = "77",

pages = "912--915",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

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TY - JOUR

T1 - Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children

AU - Martinez-Roig, A.

AU - Cami, J.

AU - Llorens-Terol, J.

AU - de la Torre, R.

AU - Perich, F.

PY - 1986/9/24

Y1 - 1986/9/24

N2 - We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.

AB - We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.

M3 - Article

SN - 0031-4005

VL - 77

SP - 912

EP - 915

JO - Pediatrics

JF - Pediatrics

IS - 6

ER -

Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children

Resum

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