TY - JOUR
T1 - Absence of thallium-201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients
AU - Iranzo, A.
AU - Marti-Fabregas, J.
AU - Domingo, P.
AU - Catafau, A.
AU - Molet, J.
AU - Moreno, A.
AU - Pujol, J.
AU - Matias-Guiu, X.
AU - Cadafalch, J.
PY - 1999/7/22
Y1 - 1999/7/22
N2 - Objective - To evaluate the presence of thallium-201 brain uptake determined by thallium-201 brain SPECT (T1-201 SPECT) in patients with progressive multifocal leukoencephalopathy (PML) and AIDS. Material and methods - Six AIDS patients with stereotactic biopsy diagnosis of PML were prospectively evaluated with T1-201 SPECT, Magnetic Resonance Imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS). T1-201 SPECT results were compared with 2 patients with AIDS and biopsy proven primary CNS lymphoma. Results -In all patients with PML, T1-201 SPECT studies showed lack of uptake while MRI demonstrated subcortical white matter focal brain lesions and 1H-MRS disclosed metabolic abnormalities. Intense thallium uptake (uptake ratios of 3.2 and 5.6) was demonstrated in the 2 patients with primary CNS lymphoma. Conclusions - The present study shows that PML lesions are not detectable on T1-201 SPECT while MRI and 1H-MRS demonstrate abnormalities, and intense thallium-201 uptake may be detected in primary CNS lymphoma. These results suggest that T1-201 SPECT is a method which, combined with other non-invasive techniques such as MRI and 1H-MRS, may help in the diagnostic approach of PML and to differentiate PML from other high proliferative brain lesions characterized by positive thallium uptake.
AB - Objective - To evaluate the presence of thallium-201 brain uptake determined by thallium-201 brain SPECT (T1-201 SPECT) in patients with progressive multifocal leukoencephalopathy (PML) and AIDS. Material and methods - Six AIDS patients with stereotactic biopsy diagnosis of PML were prospectively evaluated with T1-201 SPECT, Magnetic Resonance Imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS). T1-201 SPECT results were compared with 2 patients with AIDS and biopsy proven primary CNS lymphoma. Results -In all patients with PML, T1-201 SPECT studies showed lack of uptake while MRI demonstrated subcortical white matter focal brain lesions and 1H-MRS disclosed metabolic abnormalities. Intense thallium uptake (uptake ratios of 3.2 and 5.6) was demonstrated in the 2 patients with primary CNS lymphoma. Conclusions - The present study shows that PML lesions are not detectable on T1-201 SPECT while MRI and 1H-MRS demonstrate abnormalities, and intense thallium-201 uptake may be detected in primary CNS lymphoma. These results suggest that T1-201 SPECT is a method which, combined with other non-invasive techniques such as MRI and 1H-MRS, may help in the diagnostic approach of PML and to differentiate PML from other high proliferative brain lesions characterized by positive thallium uptake.
KW - AIDS
KW - Progressive multifocal leukoencephalopathy
KW - Thallium-201 brain SPECT
U2 - 10.1111/j.1600-0404.1999.tb01046.x
DO - 10.1111/j.1600-0404.1999.tb01046.x
M3 - Article
SN - 0001-6314
VL - 100
SP - 102
EP - 105
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 2
ER -
