TY - JOUR
T1 - A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists
AU - López-Rodríguez, María L.
AU - Benhamú, Bellinda
AU - De La Fuente, Tania
AU - Sanz, Arantxa
AU - Pardo, Leonardo
AU - Campillo, Mercedes
PY - 2005/6/30
Y1 - 2005/6/30
N2 - Forty-five structurally diverse 5-hydroxytryptamine6 receptor (5-HT6R) antagonists were selected to develop a 3D pharmacophore model with the Catalyst software. The structural features for antagonism at this receptor are a positive ionizable atom interacting with Asp3.32, a hydrogen bond acceptor group interacting with Ser5.43 and Asn 6.55, a hydrophobic site interacting with residues in a hydrophobic pocket between transmembranes 3, 4, and 5, and an aromatic-ring hydrophobic site interacting with Phe6.52. © 2005 American Chemical Society.
AB - Forty-five structurally diverse 5-hydroxytryptamine6 receptor (5-HT6R) antagonists were selected to develop a 3D pharmacophore model with the Catalyst software. The structural features for antagonism at this receptor are a positive ionizable atom interacting with Asp3.32, a hydrogen bond acceptor group interacting with Ser5.43 and Asn 6.55, a hydrophobic site interacting with residues in a hydrophobic pocket between transmembranes 3, 4, and 5, and an aromatic-ring hydrophobic site interacting with Phe6.52. © 2005 American Chemical Society.
UR - https://www.scopus.com/pages/publications/21244446301
U2 - 10.1021/jm050247c
DO - 10.1021/jm050247c
M3 - Article
SN - 0022-2623
VL - 48
SP - 4216
EP - 4219
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
ER -