A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover

Roshan K. Dhungana; Albert Granados; Mohammed Sharique; Jadab Majhi; Gary A. Molander

doi:10.1039/D2CC04101D

A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover

Roshan K. Dhungana, Albert Granados, Mohammed Sharique, Jadab Majhi, Gary A. Molander

Departament de Química

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Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.

Idioma original	Anglès
Pàgines (de-a)	9556-9559
Nombre de pàgines	4
Revista	Chemical Communications
Volum	58
DOIs	https://doi.org/10.1039/D2CC04101D
Estat de la publicació	Publicada - 2022

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10.1039/D2CC04101D

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https://www.scopus.com/pages/publications/85135723059

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@article{c9d848ed76b9481f9f48df22fe35c1fd,

title = "A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover",

abstract = "Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.",

author = "Dhungana, \{Roshan K.\} and Albert Granados and Mohammed Sharique and Jadab Majhi and Molander, \{Gary A.\}",

year = "2022",

doi = "10.1039/D2CC04101D",

language = "English",

volume = "58",

pages = " 9556--9559",

}

TY - JOUR

T1 - A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover

AU - Dhungana, Roshan K.

AU - Granados, Albert

AU - Sharique, Mohammed

AU - Majhi, Jadab

AU - Molander, Gary A.

PY - 2022

Y1 - 2022

N2 - Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.

AB - Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.

UR - https://www.scopus.com/pages/publications/85135723059

U2 - 10.1039/D2CC04101D

DO - 10.1039/D2CC04101D

M3 - Article

SN - 1359-7345

VL - 58

SP - 9556

EP - 9559

JO - Chemical Communications

JF - Chemical Communications

ER -

A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover

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