A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior

Ainhoa Plaza-Zabala, África Flores, Elena Martín-García, Rocío Saravia, Rafael Maldonado, Fernando Berrendero*

*Autor corresponent d’aquest treball

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55 Cites (Scopus)

Resum

Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by nicotine-associated cues. Pretreatment with the hypocretin receptor-1 antagonist SB334867, but not with the hypocretin receptor-2 antagonist TCSOX229, attenuated cue-induced reinstatement of nicotine-seeking, which was associated with an activation of hypocretin neurons of the lateral and perifornical hypothalamic areas. In addition, relapse to nicotine-seeking increased the phosphorylation levels of GluR2-Ser880, NR1-Ser890, and p38 MAPK in the nucleus accumbens (NAc), but not in the prefrontal cortex. Notably,
Idioma originalAnglès
Pàgines (de-a)1724-1736
Nombre de pàgines13
RevistaNeuropsychopharmacology
Volum38
Número9
DOIs
Estat de la publicacióPublicada - d’ag. 2013

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