TY - JOUR
T1 - A randomized comparison of levobupivacaine, bupivacaine and ropivacaine with fentanyl, for labor analgesia
T2 - International Journal of Obstetric Anesthesia
AU - Atiénzar, M.C.
AU - Palanca, J.Ma.
AU - Torres, F.
AU - Borràs, R.
AU - Gil, S.
AU - Esteve, I.
N1 - Cited By :20
Export Date: 17 February 2022
CODEN: IOANE
Correspondence Address: Atiénzar, M.C.; Department of Anesthesia, , Barcelona, Spain; email: [email protected]
Chemicals/CAS: bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5; fentanyl, 437-38-7; levobupivacaine, 27262-47-1, 27262-48-2; ropivacaine, 84057-95-4; Adjuvants, Anesthesia; Amides; Anesthetics, Combined; Anesthetics, Local; Bupivacaine, 2180-92-9; Fentanyl, 437-38-7; levobupivacaine; ropivacaine, 84057-95-4
References: Rutten, A.J., Nancarrow, C., Mather, L.A., Isley, A.H., Runciman, W.B., Upton, R.N., Hemodynamic and central nervous system effects of lidocaine, bupivacaine and ropivacaine in sheep (1989) Anesth Analg, 69, pp. 291-299; Huang, Y.F., Pryor, M.E., Mather, L.E., Veering, B.T., Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep (1998) Anesth Analg, 86, pp. 797-804; Morrison, S.G., Dominguez, J.J., Frascarolo, P., Reiz, S., A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine and ropivacaine in anesthetized swine (2000) Anesth Analg, 90, pp. 1308-1314; Lyons, G., Columb, M., Hawthorne, L., Dresner, M., Extradural pain relief labour: bupivacaine sparing by extradural fentanyl is dose dependent (1997) Br J Anaesth, 78, pp. 493-497; Robinson, A.P., Lyons, G.R., Wilson, R.C., Gorton, H.J., Columb, M.O., Levobupivacaine for extradural analgesia in labor; the sparing effect of epidural fentanyl (2001) Anesth Analg, 92, pp. 410-414; Atienzar, M.C., Palanca, J.M., Borras, R., Esteve, I., Fernandez, M., Miranda, A., Ropivacaine 0.1% with fentanyl 2 μg/mL by epidural infusion for labour analgesia (2004) Eur J Anaesthesiol, 21, pp. 770-775; The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. The Lancet 2001; 357: 1191-4; Lyons, G., Columb, M., Wilson, R.C., Johnson, R.V., Epidural pain relief in labour: potencies of levobupivacaine and racemic bupivacaine (1998) Br J Anaesth, 81, pp. 899-901; Caponga, G., Celleno, D., Fusco, P., Lyons, G., Columb, M., Relative potencies of bupivacaine and ropivacaine for analgesia in labour (1999) Br J Anaesth, 82, pp. 371-373; Schug, S.A., Correction factor for comparison between levobupivacaine and racemic bupivacaine (2001) Reg Anesth Pain Med, 26, p. 91; Benhamou, D., Ghosh, C., Mercier, F.J., A randomized sequential allocation study to determine the minimum effective analgesic concentration of levobupivacaine and ropivacaine in patients receiving epidural analgesia for labor (2003) Anesthesiology, 99, pp. 1383-1386; Polley, L.S., Columb, M.O., Naughton, N.N., Wagner, D.S., van de Ven, C.J., Goralski, K.H., Relative analgesic potencies of levobupivacaine and ropivacaine for epidural analgesia in labor (2003) Anesthesiology, 99, pp. 1354-1358; Purdie, N.L., McGrady, E.M., Comparison of patient-controlled epidural bolus administration of 0,1% ropivacaine and 0,1% levobupivacaine, both with 0.0002% fentanyl for analgesia during labour (2004) Anaesthesia, 59, pp. 133-137; Supandji, M., Sia, A.T.H., Ocampo, C.E., 0,2% ropivacaine and levobupivacaine provide equally effective epidural labor analgesia (2004) Can J Anesth, 51, pp. 918-922; Lacassie, H.J., Columb, M.O., The relative motor blocking potencies of bupivacaine and levobupivacaine in labor (2003) Anesth Analg, 97, pp. 1509-1513; Lim, Y., Ocampo, C.E., Sia, A.T., A comparison of duration of analgesia of intratecal 2.5 mg of bupivacaine, ropivacaine and levobupivacaine in combined spinal epidural analgesia for patients in labor (2004) Anesth Analg, 98, pp. 235-239; Camorcia, M., Capogna, G., Epidural levobupivacaine, ropivacaine and bupivacaine in combination with sufentanil in early labour: a randomized trial (2003) Eur J Anaesthesiol, 20, pp. 636-639; Burke, D., Henderson, D.J., Simpson, A.M., Comparison of 0.25% S(-)-bupivacaine with RS-bupivacaine for epidural analgesia in labour (1999) Br J Anaesth, 83, pp. 750-755
PY - 2008/4
Y1 - 2008/4
N2 - Background: To compare the analgesic efficacy of epidural infusions of levobupivacaine, bupivacaine and ropivacaine in labor. Methods: 102 nulliparous parturients in early labor were enrolled in this randomized, double-blind clinical trial. They were randomly assigned to receive one of three continuous epidural infusion regimens: levobupivacaine 0.125%, bupivacaine 0.125% or ropivacaine 0.2%, all with fentanyl 1 μg/mL at 8 mL/h. Supplementary analgesia was provided with an 8-mL epidural bolus of the study solution if visual analogue scale (VAS) score for pain was ≥40 (0-100 mm). Pain and motor and sensory block were measured at 0, 15 and 30 min, 1, 2, 3 and 4 h and full cervical dilatation. Results: Analgesia was satisfactory in all three groups, with VAS score
AB - Background: To compare the analgesic efficacy of epidural infusions of levobupivacaine, bupivacaine and ropivacaine in labor. Methods: 102 nulliparous parturients in early labor were enrolled in this randomized, double-blind clinical trial. They were randomly assigned to receive one of three continuous epidural infusion regimens: levobupivacaine 0.125%, bupivacaine 0.125% or ropivacaine 0.2%, all with fentanyl 1 μg/mL at 8 mL/h. Supplementary analgesia was provided with an 8-mL epidural bolus of the study solution if visual analogue scale (VAS) score for pain was ≥40 (0-100 mm). Pain and motor and sensory block were measured at 0, 15 and 30 min, 1, 2, 3 and 4 h and full cervical dilatation. Results: Analgesia was satisfactory in all three groups, with VAS score
KW - Analgesia: obstetric, epidural
KW - Anesthetics, local: levobupivacaine, bupivacaine, ropivacaine
KW - Opioids: fentanyl
KW - bupivacaine
KW - fentanyl
KW - levobupivacaine
KW - ropivacaine
KW - adult
KW - article
KW - birth
KW - clinical trial
KW - comparative study
KW - continuous infusion
KW - controlled clinical trial
KW - controlled study
KW - double blind procedure
KW - female
KW - human
KW - hypotension
KW - labor
KW - labor pain
KW - labor stage
KW - major clinical study
KW - motor system
KW - nausea
KW - nullipara
KW - obstetric analgesia
KW - pruritus
KW - randomized controlled trial
KW - sensory system
KW - statistical significance
KW - uterine cervix dilatation
KW - visual analog scale
KW - Adjuvants, Anesthesia
KW - Adult
KW - Amides
KW - Analgesia, Epidural
KW - Analgesia, Obstetrical
KW - Analysis of Variance
KW - Anesthetics, Combined
KW - Anesthetics, Local
KW - Bupivacaine
KW - Double-Blind Method
KW - Female
KW - Fentanyl
KW - Humans
KW - Labor Pain
KW - Motor Activity
KW - Pain Measurement
KW - Pregnancy
KW - Treatment Outcome
UR - http://www.ncbi.nlm.nih.gov/pubmed/18295469
U2 - 10.1016/j.ijoa.2007.10.003
DO - 10.1016/j.ijoa.2007.10.003
M3 - Article
C2 - 18295469
SN - 0959-289X
VL - 17
SP - 106
EP - 111
JO - International Journal of Obstetric Anesthesia
JF - International Journal of Obstetric Anesthesia
IS - 2
ER -