A rabbit model of corneal endothelial disease induced by intracameral injection of 0,05% benzalkonium chloride

Sergi Segarra; Marta Leiva Repiso; Daniel Costa Moya; Natàlia Coyo; Maria Sabés Alsina; Jose Ríos; Carolina Naranjo; Maria Teresa Peña Gimenez

A rabbit model of corneal endothelial disease induced by intracameral injection of 0,05% benzalkonium chloride

Sergi Segarra, Marta Leiva Repiso, Daniel Costa Moya, Natàlia Coyo, Maria Sabés Alsina, Jose Ríos, Carolina Naranjo, Maria Teresa Peña Gimenez

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Resum

Rabbits are currently not suitable to be used as an animal model of corneal endothelial disorders because their corneal endothelial cells (CEC) maintain a highly proliferative capacity in vivo. A recent ex vivo study suggests that intracameral injection (ICI) of 0.1 mL 0.05% benzalkonium chloride (BAC) in rabbits produces a selective endothelial damage. This study was aimed at evaluating the effects of BAC ICI in rabbits in vivo to define the most appropriate BAC dose for inducing a rabbit model of corneal endothelial disease.

Idioma original	Anglès nord-americà
Pàgines (de-a)	344-351
Nombre de pàgines	8
Revista	International Journal of Ophthalmic Research
Volum	6
Número	1
Estat de la publicació	Publicada - d’oct. 2020

Com citar-ho

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title = "A rabbit model of corneal endothelial disease induced by intracameral injection of 0,05\% benzalkonium chloride",

abstract = "Rabbits are currently not suitable to be used as an animal model of corneal endothelial disorders because their corneal endothelial cells (CEC) maintain a highly proliferative capacity in vivo. A recent ex vivo study suggests that intracameral injection (ICI) of 0.1 mL 0.05\% benzalkonium chloride (BAC) in rabbits produces a selective endothelial damage. This study was aimed at evaluating the effects of BAC ICI in rabbits in vivo to define the most appropriate BAC dose for inducing a rabbit model of corneal endothelial disease.",

keywords = "Animal model, Endothelial dysfunction, Corneal endothelial cell, Specular microscopy, Pachymetry",

author = "Sergi Segarra and \{Leiva Repiso\}, Marta and \{Costa Moya\}, Daniel and Nat{\`a}lia Coyo and \{Sab{\'e}s Alsina\}, Maria and Jose R{\'i}os and Carolina Naranjo and \{Pe{\~n}a Gimenez\}, \{Maria Teresa\}",

year = "2020",

month = oct,

language = "Ingl{\'e}s estadounidense",

volume = "6",

pages = "344--351",

number = "1",

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TY - JOUR

T1 - A rabbit model of corneal endothelial disease induced by intracameral injection of 0,05% benzalkonium chloride

AU - Segarra, Sergi

AU - Leiva Repiso, Marta

AU - Costa Moya, Daniel

AU - Coyo, Natàlia

AU - Sabés Alsina, Maria

AU - Ríos, Jose

AU - Naranjo, Carolina

AU - Peña Gimenez, Maria Teresa

PY - 2020/10

Y1 - 2020/10

N2 - Rabbits are currently not suitable to be used as an animal model of corneal endothelial disorders because their corneal endothelial cells (CEC) maintain a highly proliferative capacity in vivo. A recent ex vivo study suggests that intracameral injection (ICI) of 0.1 mL 0.05% benzalkonium chloride (BAC) in rabbits produces a selective endothelial damage. This study was aimed at evaluating the effects of BAC ICI in rabbits in vivo to define the most appropriate BAC dose for inducing a rabbit model of corneal endothelial disease.

AB - Rabbits are currently not suitable to be used as an animal model of corneal endothelial disorders because their corneal endothelial cells (CEC) maintain a highly proliferative capacity in vivo. A recent ex vivo study suggests that intracameral injection (ICI) of 0.1 mL 0.05% benzalkonium chloride (BAC) in rabbits produces a selective endothelial damage. This study was aimed at evaluating the effects of BAC ICI in rabbits in vivo to define the most appropriate BAC dose for inducing a rabbit model of corneal endothelial disease.

KW - Animal model

KW - Endothelial dysfunction

KW - Corneal endothelial cell

KW - Specular microscopy

KW - Pachymetry

M3 - Artículo

SN - 2409-5680

VL - 6

SP - 344

EP - 351

JO - International Journal of Ophthalmic Research

JF - International Journal of Ophthalmic Research

IS - 1

ER -