TY - JOUR
T1 - A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis :
T2 - a metabolomic analysis
AU - Laghi, Luca
AU - Roman, Eva
AU - Lan, Qiuyu
AU - Nieto Sáchica, Juan Camilo
AU - Canalda-Baltrons, Aleix
AU - Poca Sans, Maria
AU - Sánchez-Rodríguez, Maria B.
AU - Clària, Joan
AU - Alvarado-Tapias, Edilmar
AU - Cuyàs, Berta
AU - Sánchez, Elisabet
AU - Vidal, Silvia
AU - Guarner, Carlos
AU - Escorsell, Àngels
AU - Manichanh, Chaysavanh
AU - Soriano, German
N1 - Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.
PY - 2023/4
Y1 - 2023/4
N2 - To explore the potential mechanisms underlying the effects of a probiotic in cirrhotic patients, we analyzed the blood metabolome using proton nuclear magnetic resonance (1 H-NMR) spectroscopy in 32 patients with cirrhosis and cognitive dysfunction or falls. Patients were randomized to receive a multistrain probiotic or placebo for 12 weeks. Among the 54 metabolites identified, the only significant changes in the probiotic group were an increase in glutamine, a decrease in glutamate, and an increase in the glutamine/glutamate ratio. In the placebo group, glutamate increased and the glutamine/glutamate ratio decreased. Our results suggest the multistrain probiotic could influence glutamine/glutamate metabolism, increasing the capacity of ammonia detoxification.
AB - To explore the potential mechanisms underlying the effects of a probiotic in cirrhotic patients, we analyzed the blood metabolome using proton nuclear magnetic resonance (1 H-NMR) spectroscopy in 32 patients with cirrhosis and cognitive dysfunction or falls. Patients were randomized to receive a multistrain probiotic or placebo for 12 weeks. Among the 54 metabolites identified, the only significant changes in the probiotic group were an increase in glutamine, a decrease in glutamate, and an increase in the glutamine/glutamate ratio. In the placebo group, glutamate increased and the glutamine/glutamate ratio decreased. Our results suggest the multistrain probiotic could influence glutamine/glutamate metabolism, increasing the capacity of ammonia detoxification.
KW - Glutamic Acid/metabolism
KW - Glutamine/metabolism
KW - Humans
KW - Liver Cirrhosis
KW - Metabolomics/methods
KW - Probiotics/therapeutic use
UR - https://www.mendeley.com/catalogue/22a1a0ca-edb4-363d-8af9-6785a2c3b03d/
UR - https://www.scopus.com/pages/publications/85181173098
U2 - 10.1097/hc9.0000000000000072
DO - 10.1097/hc9.0000000000000072
M3 - Article
C2 - 37026745
SN - 2471-254X
VL - 7
JO - Hepatology Communications
JF - Hepatology Communications
IS - 4
ER -