TY - JOUR
T1 - A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013–2015 in Catalonia, Spain
AU - Godoy, Cristina
AU - Peremiquel-Trillas, Paula
AU - Andrés, Cristina
AU - Gimferrer, Laura
AU - Uriona, Sonia María
AU - Codina, María Gema
AU - Armadans, Lluis
AU - Martín, María del Carmen
AU - Fuentes, Francisco
AU - Esperalba, Juliana
AU - Campins, Magda
AU - Pumarola, Tomàs
AU - Antón, Andrés
PY - 2016/10/1
Y1 - 2016/10/1
N2 - © 2016 Elsevier Inc. Human parainfluenza virus type 3 (HPIV-3) is one of the most common respiratory viruses particularly among young children and immunocompromised patients. The seasonality, prevalence and genetic diversity of HPIV-3 at a Spanish tertiary-hospital from 2013 to 2015 are reported. HPIV-3 infection was laboratory-confirmed in 102 patients (76%, under 5 years of age). Among <5 years-old patients, 9 (11.5%) were under any degree of immunosuppression, whereas this percentage was significantly higher (19; 79.2%) among patients older than 5 years. HPIV-3 was detected at varying levels, but mainly during spring and summer. All characterized HN/F sequences fell within C1b, C5 and in other two closely C3a-related groups. Furthermore, a new genetic lineage (C1c) was described. Genetic similarity and epidemiological data confirmed some nosocomial infections, highlighting the importance of the HPIV-3 surveillance, particularly in high-risk patients. This study provides valuable information on HPIV-3 diversity due to the scarce information in Europe.
AB - © 2016 Elsevier Inc. Human parainfluenza virus type 3 (HPIV-3) is one of the most common respiratory viruses particularly among young children and immunocompromised patients. The seasonality, prevalence and genetic diversity of HPIV-3 at a Spanish tertiary-hospital from 2013 to 2015 are reported. HPIV-3 infection was laboratory-confirmed in 102 patients (76%, under 5 years of age). Among <5 years-old patients, 9 (11.5%) were under any degree of immunosuppression, whereas this percentage was significantly higher (19; 79.2%) among patients older than 5 years. HPIV-3 was detected at varying levels, but mainly during spring and summer. All characterized HN/F sequences fell within C1b, C5 and in other two closely C3a-related groups. Furthermore, a new genetic lineage (C1c) was described. Genetic similarity and epidemiological data confirmed some nosocomial infections, highlighting the importance of the HPIV-3 surveillance, particularly in high-risk patients. This study provides valuable information on HPIV-3 diversity due to the scarce information in Europe.
KW - Children
KW - Fusion protein
KW - Haemagglutinin-neuraminidase
KW - HPIV-3
KW - Human parainfluenza virus type 3
KW - Immunocompromised
KW - Molecular characterization
KW - Phylogenetic analysis
U2 - 10.1016/j.diagmicrobio.2016.07.023
DO - 10.1016/j.diagmicrobio.2016.07.023
M3 - Article
SN - 0732-8893
VL - 86
SP - 153
EP - 159
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -