TY - JOUR
T1 - A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes
AU - Grau-Roma, L.
AU - Galindo-Cardiel, I.
AU - Isidoro-Ayza, M.
AU - Fernández, M.
AU - Majó, N.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - © 2014 Elsevier Ltd. Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineffective. It has been hypothesized that genetically predisposed cats may develop FGESF in response to the introduction of bacteria or other antigens into the intestinal wall. A 9-month-old male Persian cat presented with a history of marked acute haematemesis. A mass (10cm diameter) was detected within the pylorus and proximal duodenum and this was not surgically accessible. On necropsy examination the duodenal wall was seen to be markedly thickened with extensive mucosal ulceration. Microscopically, there were haphazardly oriented trabecular bands of dense eosinophilic collagen, separated by wide, clear areas containing variable numbers of fibroblasts, eosinophils, mast cells, neutrophils, macrophages, lymphocytes and plasma cells. Numerous pleomorphic, non-parallel walled, sparsely septate hyphae, characteristic of phycomycetes, were present within the collagen matrix. Colonies of gram-positive and gram-negative rods were also present within the lesion. This is the first description of FGESF with intralesional fungi.
AB - © 2014 Elsevier Ltd. Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory condition of domestic cats with unknown aetiology. A proportion of cases of FGESF are associated with bacteria, but antibiotic treatment is ineffective. It has been hypothesized that genetically predisposed cats may develop FGESF in response to the introduction of bacteria or other antigens into the intestinal wall. A 9-month-old male Persian cat presented with a history of marked acute haematemesis. A mass (10cm diameter) was detected within the pylorus and proximal duodenum and this was not surgically accessible. On necropsy examination the duodenal wall was seen to be markedly thickened with extensive mucosal ulceration. Microscopically, there were haphazardly oriented trabecular bands of dense eosinophilic collagen, separated by wide, clear areas containing variable numbers of fibroblasts, eosinophils, mast cells, neutrophils, macrophages, lymphocytes and plasma cells. Numerous pleomorphic, non-parallel walled, sparsely septate hyphae, characteristic of phycomycetes, were present within the collagen matrix. Colonies of gram-positive and gram-negative rods were also present within the lesion. This is the first description of FGESF with intralesional fungi.
KW - Cat
KW - Feline gastrointestinal eosinophilic sclerosing fibroplasia
KW - Phycomycetes
U2 - 10.1016/j.jcpa.2014.08.005
DO - 10.1016/j.jcpa.2014.08.005
M3 - Article
SN - 0021-9975
VL - 151
SP - 318
EP - 321
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 4
ER -